Diminution of context association memory structure in subjects with subjective cognitive decline

• Published in: Human brain mapping Vol. 39; no. 6; pp. 2549 - 2562
• Main Authors: Fan, Ling‐Yun, Lai, Ya‐Mei, Chen, Ta‐Fu, Hsu, Yung‐Chin, Chen, Pin‐Yu, Huang, Kuo‐Zhou, Cheng, Ting‐Wen, Tseng, Wen‐Yi Isaac, Hua, Mau‐Sun, Chen, Ya‐Fang, Chiu, Ming‐Jang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2018; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer's disease; Analysis of Variance; Anisotropy; Atrophy; Atrophy - pathology; Brain; Brain - diagnostic imaging; Brain - physiopathology; Brain Mapping; Case-Control Studies; Cognitive ability; Cognitive Dysfunction - complications; Cognitive Dysfunction - diagnostic imaging; Cognitive tasks; Computer memory; context memory; Cortex (entorhinal); Cortex (perirhinal); Cortex (temporal); cortical thickness; Decision Making, Computer-Assisted; Dementia disorders; Disease Progression; entorhinal cortex; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory; Memory Disorders - diagnostic imaging; Memory Disorders - etiology; Memory, Episodic; Middle Aged; Neurodegenerative diseases; Neurofibrillary tangles; Neuropsychological Tests; Parahippocampal gyrus; parahippocampus; perirhinal cortex; Regression Analysis; Retrospective Studies; subjective cognitive decline; Substantia grisea; uncinate fasciculus; White Matter - diagnostic imaging; White Matter - pathology; uncinate fasciculus; subjective cognitive decline; cortical thickness; parahippocampus; context memory; entorhinal cortex; perirhinal cortex

Alzheimer's disease (AD) progresses insidiously from the preclinical stage to dementia. While people with subjective cognitive decline (SCD) have normal cognitive performance, some may be in the preclinical stage of AD. Neurofibrillary tangles appear first in the transentorhinal cortex, followe...