Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T‐cell differentiation along the maternal‐placental circulation

• Published in: Cell proliferation Vol. 53; no. 5; pp. e12802 - n/a
• Main Authors: Ma, Yeling, Yang, Qian, Fan, Mengjie, Zhang, Lanmei, Gu, Yan, Jia, Wentong, Li, Zhilang, Wang, Feiyang, Li, Yu‐xia, Wang, Jian, Li, Rong, Shao, Xuan, Wang, Yan‐Ling
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: Antibodies; Arteries; Cardiovascular system; CD4 antigen; Cell differentiation; Circulation; Decidua; Differentiation (biology); Endothelial cells; enEVTs; Enzyme-linked immunosorbent assay; Fetuses; Flow cytometry; Foxp3 protein; Hospitals; Hybridization; Immunofluorescence; Immunological tolerance; Immunoregulation; Lymphocytes; Lymphocytes T; Miscarriage; Original; Pathogenesis; Placenta; placental‐maternal circulation; Pregnancy; RSA; TGF‐β1; Transforming growth factor-b1; Tregs; Trophoblasts; Uterus; Zoology; Beijing China; China; placental-maternal circulation; RSA; enEVTs; TGF-β1; Tregs

Objectives During human pregnancy, the endothelial cells of the uterine spiral arteries (SPA) are extensively replaced by a subtype of placental trophoblasts, endovascular extravillous trophoblasts (enEVTs), thus establishing a placental‐maternal circulation. On this pathway, foetus‐derived placenta...