Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas
The transcriptional factor Snail and enzyme cyclo‐oxygenase‐2 (Cox‐2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the a...
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| Published in | Neuropathology Vol. 30; no. 3; pp. 224 - 231 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Publishing Asia
01.06.2010
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The transcriptional factor Snail and enzyme cyclo‐oxygenase‐2 (Cox‐2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the association between Snail and Cox‐2 expressions and their values as prognostic factors in various grades of glioma, Specimens of 56 patients with glioma were used in the study. Univariate analysis showed that WHO tumor grade, and expressions of Snail and Cox‐2 were significant prognostic factors affecting overall and disease progression‐free survival rates. In the multivariate analysis by Cox regression model, only WHO tumor grade was shown to be a significant independent prognostic factor of overall and progression‐free survival rates. In conclusion, Snail and Cox‐2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators. |
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| AbstractList | The transcriptional factor Snail and enzyme cyclo-oxygenase-2 (Cox-2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the association between Snail and Cox-2 expressions and their values as prognostic factors in various grades of glioma, Specimens of 56 patients with glioma were used in the study. Univariate analysis showed that WHO tumor grade, and expressions of Snail and Cox-2 were significant prognostic factors affecting overall and disease progression-free survival rates. In the multivariate analysis by Cox regression model, only WHO tumor grade was shown to be a significant independent prognostic factor of overall and progression-free survival rates. In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators. |
| Author | Kim, Young-Soon Park, Sung-Hye Myung, Jaekyung Cho, Byung-Kyu |
| Author_xml | – sequence: 1 givenname: Jaekyung surname: Myung fullname: Myung, Jaekyung organization: Departments of Pathology and – sequence: 2 givenname: Byung-Kyu surname: Cho fullname: Cho, Byung-Kyu organization: Neurosurgery, Seoul National University Hospital – sequence: 3 givenname: Young-Soon surname: Kim fullname: Kim, Young-Soon organization: Departments of Anesthesiology and pain medicine, Samsung Medical Center, Seoul, Korea – sequence: 4 givenname: Sung-Hye surname: Park fullname: Park, Sung-Hye email: shparknp@snu.ac.kr organization: Departments of Pathology and |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19925564$$D View this record in MEDLINE/PubMed |
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| Copyright | 2009 Japanese Society of Neuropathology |
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| Snippet | The transcriptional factor Snail and enzyme cyclo‐oxygenase‐2 (Cox‐2) are suggested to be important effectors of invasiveness and tumorigenesis in various... The transcriptional factor Snail and enzyme cyclo-oxygenase-2 (Cox-2) are suggested to be important effectors of invasiveness and tumorigenesis in various... |
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| SubjectTerms | Adolescent Aged Brain Neoplasms - enzymology Brain Neoplasms - mortality Brain Neoplasms - pathology Child Child, Preschool Cox-2 Cyclooxygenase 2 - biosynthesis Disease Progression Disease-Free Survival Female Follow-Up Studies Gene Expression Regulation, Neoplastic glioma Glioma - enzymology Glioma - mortality Glioma - pathology Humans immunohistochemistry Infant Male Neoplasm Staging Prognosis prognostic factor Snail Snail Family Transcription Factors Survival Rate - trends Transcription Factors - biosynthesis World Health Organization |
| Title | Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas |
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