Lessons Learned from Alzheimer Disease: Clinical Trials with Negative Outcomes

• Published in: Clinical and translational science Vol. 11; no. 2; pp. 147 - 152
• Main Author: Cummings, Jeffrey
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2018; John Wiley and Sons Inc
• Subjects: Alzheimer's disease; Amyloid; Animal cognition; Animal models; Biomarkers; Clinical trials; Cognitive ability; Dementia; Diagnosis; Drug development; Drug dosages; Hypotheses; Immunotherapy; Nervous system; Neurodegenerative diseases; Review; Reviews; Success; United States > US

Improved interpretation of animal models, better pharmacologic characterization in phase I and phase II trials, appropriate sample size, diagnosis of AD with biomarker support, optimization of global recruitment, and avoiding inappropriate subgroup analyses can improve drug development success rates...