New evidence of connections between increased O‐GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus

• Published in: Clinical and experimental immunology Vol. 192; no. 1; pp. 129 - 137
• Main Authors: Thi Do, T., Phoomak, C., Champattanachai, V., Silsirivanit, A., Chaiyarit, P.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2018; John Wiley and Sons Inc
• Subjects: Acetylglucosamine - metabolism; Adolescent; Adult; Aged; Biopsy; Case-Control Studies; Female; Glycosylation; Humans; Immune response; Immunohistochemistry; Immunopathogenesis; inflammasome; Inflammasomes; Inflammasomes - genetics; Inflammasomes - metabolism; inflammation; Lichen planus; Lichen Planus, Oral - immunology; Male; Middle Aged; Mouth Mucosa - pathology; Mucosa; NF-kappa B - genetics; NF-kappa B - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; O-GlcNAcylation; oral lichen planus; Original; pathogenesis; Pyrin protein; Signal Transduction; Young Adult; pathogenesis; O-GlcNAcylation; oral lichen planus; inflammation; inflammasome

Summary Oral lichen planus (OLP) is considered a chronic inflammatory immune‐mediated disease of the oral mucosa. Immunopathogenesis of OLP is thought to be associated with cell‐mediated immune dysregulation. O‐GlcNAcylation is a form of reversible glycosylation. It has been demonstrated that O‐GlcN...