Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative,...

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Published inBritish journal of pharmacology Vol. 177; no. 6; pp. 1258 - 1277
Main Authors Cheng, Chak Kwong, Luo, Jiang‐Yun, Lau, Chi Wai, Chen, Zhen‐Yu, Tian, Xiao Yu, Huang, Yu
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.03.2020
John Wiley and Sons Inc
Subjects
Aging
Anti-Inflammatory Agents
Antioxidants
Arteriosclerosis
Cardiomyopathy
Cardiovascular diseases
Cardiovascular System
Circadian rhythms
Developmental stages
Dietary Supplements
Energy metabolism
Functional foods & nutraceuticals
Inflammation
Ischemia
Microbiota
Phytoalexins
Resveratrol
Resveratrol - pharmacology
Review
Themed Section: Review
Wine
Online AccessGet full text
ISSN0007-1188
1476-5381
1476-5381
DOI10.1111/bph.14801

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Abstract Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
AbstractList Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
Resveratrol (trans-3,4',5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angio-regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol-induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti-aging agent against several age-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.
Resveratrol (trans-3,4',5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angio-regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol-induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti-aging agent against several age-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.Resveratrol (trans-3,4',5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angio-regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol-induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti-aging agent against several age-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.
Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.Linked ArticlesThis article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
Author Lau, Chi Wai
Luo, Jiang‐Yun
Cheng, Chak Kwong
Chen, Zhen‐Yu
Tian, Xiao Yu
Huang, Yu
AuthorAffiliation 1 Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong SAR China
2 Food and Nutritional Sciences Programme, School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR China
AuthorAffiliation_xml – name: 2 Food and Nutritional Sciences Programme, School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR China
– name: 1 Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong SAR China
Author_xml – sequence: 1
  givenname: Chak Kwong
  surname: Cheng
  fullname: Cheng, Chak Kwong
  organization: The Chinese University of Hong Kong
– sequence: 2
  givenname: Jiang‐Yun
  surname: Luo
  fullname: Luo, Jiang‐Yun
  organization: The Chinese University of Hong Kong
– sequence: 3
  givenname: Chi Wai
  surname: Lau
  fullname: Lau, Chi Wai
  organization: The Chinese University of Hong Kong
– sequence: 4
  givenname: Zhen‐Yu
  surname: Chen
  fullname: Chen, Zhen‐Yu
  organization: The Chinese University of Hong Kong
– sequence: 5
  givenname: Xiao Yu
  surname: Tian
  fullname: Tian, Xiao Yu
  organization: The Chinese University of Hong Kong
– sequence: 6
  givenname: Yu
  orcidid: 0000-0002-1277-6784
  surname: Huang
  fullname: Huang, Yu
  email: yu-huang@cuhk.edu.hk
  organization: The Chinese University of Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31347157$$D View this record in MEDLINE/PubMed
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Snippet Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports...
Resveratrol (trans-3,4',5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports...
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SubjectTerms Aging
Anti-Inflammatory Agents
Antioxidants
Arteriosclerosis
Cardiomyopathy
Cardiovascular diseases
Cardiovascular System
Circadian rhythms
Developmental stages
Dietary Supplements
Energy metabolism
Functional foods & nutraceuticals
Inflammation
Ischemia
Microbiota
Phytoalexins
Resveratrol
Resveratrol - pharmacology
Review
Themed Section: Review
Wine
Title Pharmacological basis and new insights of resveratrol action in the cardiovascular system
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbph.14801
https://www.ncbi.nlm.nih.gov/pubmed/31347157
https://www.proquest.com/docview/2370740315
https://www.proquest.com/docview/2265750997
https://pubmed.ncbi.nlm.nih.gov/PMC7056472
Volume 177
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