Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation

• Published in: The Journal of pathology Vol. 252; no. 4; pp. 371 - 383
• Main Authors: Li, Fengyuan, Zhao, Cuiqing, Shao, Tuo, Liu, Yunhuan, Gu, Zelin, Jiang, Mengwei, Li, Huimin, Zhang, Lihua, Gillevet, Patrick M, Puri, Puneet, Deng, Zhong‐Bin, Chen, Shao‐Yu, Barve, Shirish, Gobejishvili, Leila, Vatsalya, Vatsalya, McClain, Craig J, Feng, Wenke
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2020; Wiley Subscription Services, Inc
• Subjects: Alcohol use; ALD; Animals; Antimicrobial agents; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - metabolism; Antimicrobial peptides; Biomarkers - blood; Cell activation; CRAMP; Dysbacteriosis; Dysbiosis - genetics; Dysbiosis - metabolism; Dysbiosis - pathology; Hepatitis; Homeostasis; Humans; IL‐1β; Inflammasomes; Inflammasomes - genetics; Inflammasomes - metabolism; Interleukin-1beta - blood; Lipopolysaccharides; Liver - metabolism; Liver - pathology; Liver diseases; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - metabolism; Liver Diseases, Alcoholic - pathology; LPS; Macrophages; Male; Mice; Mice, Knockout; Oxidative Stress - genetics; Peptides; Serum levels; Uric acid; Uric Acid - blood; IL‐1β; ALD; CRAMP; uric acid; LPS

Alcoholic liver disease (ALD) is associated with gut dysbiosis and hepatic inflammasome activation. While it is known that antimicrobial peptides (AMPs) play a critical role in the regulation of bacterial homeostasis in ALD, the functional role of AMPs in the alcohol‐induced inflammasome activation...