World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom

• Published in: Addiction (Abingdon, England) Vol. 115; no. 9; pp. 1668 - 1680
• Main Authors: Witkiewitz, Katie, Heather, Nick, Falk, Daniel E., Litten, Raye Z., Hasin, Deborah S., Kranzler, Henry R., Mann, Karl F., O'Malley, Stephanie S., Anton, Raymond F.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2020
• Subjects: Acamprosate; Acamprosate - therapeutic use; Adult; Alcohol; Alcohol dependence; Alcohol Deterrents - therapeutic use; Alcohol Drinking - epidemiology; Alcohol Drinking - therapy; alcohol treatment outcomes; Alcohol use; alcohol use disorder; Alcohol-Related Disorders - epidemiology; Alcohol-Related Disorders - therapy; Alcoholism; Alcoholism - epidemiology; Alcoholism - therapy; Behavior modification; Behavior Therapy; Clinical research; Clinical trials; Diagnostic and Statistical Manual; Drinking behavior; Drug dependence; Drug therapy; Drugs; Female; Health services utilization; Health Surveys; Help seeking behavior; Humans; Intervention; Liver; low‐risk drinking; Male; Mental disorders; Mental Health; Middle Aged; Motivational Interviewing; Naltrexone; Naltrexone - therapeutic use; Network therapy; Patients; Questionnaires; reduced alcohol consumption; Risk; Risk assessment; Severity; Social behavior; Social organization; Substance abuse treatment; Treatment Outcome; United Kingdom - epidemiology; United States - epidemiology; World Health Organization; World Health Organization risk drinking levels; United States; United Kingdom; United Kingdom > UK; United States > US; alcohol use disorder; alcohol treatment outcomes; Alcohol dependence; World Health Organization risk drinking levels; reduced alcohol consumption; low-risk drinking

Aims To examine whether World Health Organization (WHO) risk‐level reductions in drinking were achievable, associated with improved functioning and maintained over time among patients at varying initial alcohol dependence severity levels. Design and setting Secondary data analysis of multi‐site rand...