Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome

• Published in: Journal of cellular physiology Vol. 233; no. 3; pp. 2067 - 2074
• Main Authors: Yamanaka, Yoshiaki, Gingery, Anne, Oki, Gosuke, Yang, Tai‐Hua, Zhao, Chunfeng, Amadio, Peter C.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2018
• Subjects: Carpal tunnel syndrome; Carpal Tunnel Syndrome - drug therapy; Carpal Tunnel Syndrome - pathology; Cells, Cultured; Collagen (type I); Collagen (type III); Collagen Type I - biosynthesis; Collagen Type I - genetics; Collagen Type III - biosynthesis; Collagen Type III - genetics; Connective Tissue - pathology; Connective Tissue Cells - cytology; Connective tissue growth factor; Connective Tissue Growth Factor - biosynthesis; Connective Tissue Growth Factor - genetics; Connective tissues; Down-regulation; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; Fibroblasts; Fibroblasts - metabolism; Fibrosis; Fibrosis - drug therapy; Fibrosis - pathology; Gene expression; Gene regulation; Genes; Growth factors; Humans; Inhibition; Overuse injuries; Patients; Plasminogen Activator Inhibitor 1 - biosynthesis; Plasminogen Activator Inhibitor 1 - genetics; Platelet-derived growth factor; Polymerase chain reaction; Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors; Receptors, Transforming Growth Factor beta - antagonists & inhibitors; Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors; Signal transduction; Signaling; Smad protein; subsynovial connective tissue; Synovial Membrane - cytology; Synovial Membrane - pathology; Transforming Growth Factor beta - metabolism; transforming growth factor β; Vascular endothelial growth factor; Vascular endothelial growth factor receptors; carpal tunnel syndrome; fibrosis; subsynovial connective tissue; transforming growth factor β

Fibrosis of the subsynovial connective tissue (SSCT) in carpal tunnel syndrome (CTS) patients is increasingly recognized as an important aspect of CTS pathophysiology. In this study, we evaluated the effect of blocking profibrotic pathways in fibroblasts from the SSCT in CTS patients. Fibroblasts we...