Evidence of potent humoral immune activity in COVID‐19‐infected kidney transplant recipients

• Published in: American journal of transplantation Vol. 20; no. 11; pp. 3149 - 3161
• Main Authors: Hartzell, Susan, Bin, Sofia, Benedetti, Claudia, Haverly, Meredith, Gallon, Lorenzo, Zaza, Gianluigi, Riella, Leonardo V., Menon, Madhav C., Florman, Sander, Rahman, Adeeb H., Leech, John M., Heeger, Peter S., Cravedi, Paolo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.11.2020; John Wiley and Sons Inc
• Subjects: Adaptive immunity; Anergy; Brief Communication; Brief Communications; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell surface; Comorbidity; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 - immunology; Female; Flow cytometry; Humans; immune regulation; Immunity, Humoral; immunobiology; Immunocompromised Host; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunological memory; immunosuppressant – other; Immunosuppression; immunosuppression/immune modulation; Immunosuppressive agents; infection and infectious agents – viral; Kidney transplantation; Kidney Transplantation - adverse effects; kidney transplantation/nephrology; Kidney transplants; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Memory cells; Middle Aged; Pandemics; Peripheral blood; Phenotypes; Phenotyping; Renal Insufficiency - epidemiology; Renal Insufficiency - surgery; Retrospective Studies; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; translational research/science; Transplant Recipients; United States - epidemiology; United States; translational research/science; immunosuppressant - other; immunosuppression/immune modulation; kidney transplantation/nephrology; immunobiology; infection and infectious agents - viral; immune regulation

Whether kidney transplant recipients are capable of mounting an effective anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surf...