Probiotic Escherichia coli Nissle 1917 inhibits bacterial persisters that survive fluoroquinolone treatment

• Published in: Journal of applied microbiology Vol. 132; no. 6; pp. 4020 - 4032
• Main Authors: Hare, Patricia J., Englander, Hanna E., Mok, Wendy W. K.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2022
• Subjects: Anti-Bacterial Agents - pharmacology; antibiotic treatment failure; Antibiotics; Antiinfectives and antibacterials; Bacteria; Diffusion cells; DNA damage; E coli; E. coli Nissle; Efflux; Escherichia coli; Escherichia coli Proteins; fluoroquinolones; Fluoroquinolones - pharmacology; Infections; microbial interference; Microorganisms; persisters; Probiotics; Probiotics - pharmacology; Progeny; Resistant mutant; Resuscitation; SOS response; microbial interference; persisters; fluoroquinolones; antibiotic treatment failure; E. coli Nissle; probiotics

Aims Bacterial persisters are rare phenotypic variants in clonal bacterial cultures that can endure antimicrobial therapy and potentially contribute to infection relapse. Here, we investigate the potential of leveraging microbial interactions to disrupt persisters as they resuscitate during the post...