Retrospective study of umbilical cord ulceration related to congenital intestinal atresia: A single‐center report

• Published in: The journal of obstetrics and gynaecology research Vol. 44; no. 5; pp. 873 - 879
• Main Authors: Nakamura, Eishin, Samejima, Kouki, Takayanagi, Natsuko, Ono, Yoshihisa, Matsunaga, Shigetaka, Nagai, Tomonori, Takai, Yasushi, Saitoh, Masahiro, Baba, Kazunori, Seki, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01.05.2018; Wiley Subscription Services, Inc
• Subjects: Age; congenital intestinal atresia; Duodenum; Fetuses; Gestational age; inducting labor; Intestine; intra‐uterine fetal death; intra‐uterine hemorrhage; Jejunum; Umbilical cord; umbilical cord ulceration; Uterus; congenital intestinal atresia; umbilical cord ulceration; inducting labor; intra-uterine fetal death; intra-uterine hemorrhage
• DOI: 10.1111/jog.13611
• ISSN: 1341-8076

Aim Umbilical cord ulceration (UCU) is a disease in which an ulcer forms in the umbilical cord in the pregnant uterus and is accompanied by hemorrhaging from the same site. UCU occurs in fetuses with congenital upper‐intestinal atresia (CUIA); however, its onset mechanism remains unclear. Here, we report our investigation of cases of UCU in our hospital. Methods Among the 9825 deliveries performed between 2007 and 2016 at this hospital, 20 fetuses were diagnosed with CUIA, 4 (20%) of which had UCU. There was no difference in the backgrounds of the fetuses with UCU (UCU group: 4 fetuses) and those without (non‐UCU group: 16 fetuses). Results There was no intergroup difference in gestational age at delivery. Four cases in the UCU group had maternal age 35 weeks (26–39), weeks of delivery 35 weeks (35–36) and weight 2178.5 g (1600–2640); three out of four fetuses were female; and the location of gastrointestinal obstruction was in the duodenum in one case and in the jejunum in three cases. Death occurred in three of four fetuses in the UCU group versus none in the non‐UCU group. Conclusion We performed a retrospective statistical investigation on the risk of UCU onset in cases from this hospital; however, we could not identify any prognostic factors for its onset. We investigated a total of 27 past reported UCU cases and the 4 cases in this study. Mean gestational age at onset was 33.3 ± 2.7 for all 27 cases. Various methods for the early discovery of UCU have been reported in the past; however, there is currently no gold standard. Based on this report and a review of past papers, for CUIA, it is desirable to perform in‐hospital management from gestational week 30 onward and decide proper delivery timing on a case‐by‐case basis.