Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway

• Published in: Journal of cellular physiology Vol. 234; no. 5; pp. 6298 - 6312
• Main Authors: Chowdhury, Indrajit, Banerjee, Saswati, Driss, Adel, Xu, Wei, Mehrabi, Sherifeh, Nezhat, Ceana, Sidell, Neil, Taylor, Robert N., Thompson, Winston E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019; John Wiley and Sons Inc
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Chemokines; Curcumin; Curcumin - pharmacology; Cytokines; Cytokines - drug effects; Cytokines - immunology; Cytokines - metabolism; Endometriosis; Endometriosis - immunology; Endometriosis - metabolism; Endometriosis - pathology; Endometrium; Endometrium - drug effects; Endometrium - immunology; Endometrium - pathology; Female; Fertility; Gonadotropin-releasing hormone; human; Humans; Immune system; Infertility; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; NF-kappa B - drug effects; NF-kappa B - metabolism; Original; Original s; Pain; Phosphorylation; Progesterone; Progestin; Side effects; Signal transduction; Signal Transduction - drug effects; Signaling; Stat3 protein; Steroids; stromal cell; Stromal cells; Stromal Cells - drug effects; Stromal Cells - immunology; Stromal Cells - pathology; Traditional medicine; stromal cell; endometriosis; human; curcumin

Endometriosis is a chronic gynecological inflammatory disorder in which immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, eutopic endometriotic tissues have an attenuated response t...