Bacterial lysate add‐on therapy to reduce exacerbations in severe asthma: A double‐blind placebo‐controlled trial

• Published in: Clinical and experimental allergy Vol. 51; no. 9; pp. 1172 - 1184
• Main Authors: Boer, Geertje M., Braunstahl, Gert‐Jan, Ploeg, Esmee K., Zelst, Cathelijne M., Bruggen, Alie, Epping, Guido, Nimwegen, Menno, Verhoeven, Gert, Birnie, Erwin, Boxma‐de Klerk, Bianca M., Bruijn, Marjolein J. W., Stadhouders, Ralph, Hendriks, Rudi W., Tramper‐Stranders, Gerdien A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2021; John Wiley and Sons Inc
• Subjects: Adjuvants, Immunologic - therapeutic use; Adolescent; Adult; Asthma; Asthma - drug therapy; Asthma - immunology; Bacteria; bacterial lysates; Cell Extracts - therapeutic use; Clinical Trial; Double-Blind Method; Double-blind studies; exacerbations; Female; Humans; immune modulation; Immunoregulation; Inflammation; Interferon; Lymphocytes T; Lysates; Male; Middle Aged; Original; Patients; Peripheral blood; Placebos; Respiratory tract diseases; Statistical analysis; type 2 inflammation; Young Adult; bacterial lysates; asthma; immune modulation; type 2 inflammation; exacerbations

Background Asthma exacerbations are frequently induced by respiratory tract infections (RTIs). Bacterial lysates have been described to possess immune‐modulatory effects and reduce RTIs as well as asthma symptoms in children. However, whether bacterial lysates have similar effects in adult asthma pa...