Incapacity to control emotion in major depression may arise from disrupted white matter integrity and OFC‐amygdala inhibition

• Published in: CNS neuroscience & therapeutics Vol. 24; no. 11; pp. 1053 - 1062
• Main Authors: Zheng, Kai‐Zhong, Wang, Hua‐Ning, Liu, Jian, Xi, Yi‐Bin, Li, Liang, Zhang, Xi, Li, Jia‐Ming, Yin, Hong, Tan, Qing‐Rong, Lu, Hong‐Bing, Li, Bao‐Juan
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2018; John Wiley and Sons Inc
• Subjects: Adult; Amygdala; Amygdala - diagnostic imaging; Amygdala - drug effects; Amygdala - physiopathology; Antidepressive Agents - therapeutic use; Brain Mapping; Cortex (frontal); Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - drug therapy; dynamic causal modeling; effective connectivity; Emotions - drug effects; Emotions - physiology; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - drug effects; Frontal Lobe - physiopathology; Functional magnetic resonance imaging; Hemispheric laterality; Humans; Image Processing, Computer-Assisted; Limbic system; Magnetic Resonance Imaging; major depressive disorder; Male; Mental depression; Middle Aged; Myelination; Neural Pathways - diagnostic imaging; Neural Pathways - drug effects; Original; Patients; Psychiatric Status Rating Scales; Substantia alba; uncinate fasciculus; White Matter - diagnostic imaging; White Matter - drug effects; white matter integrity; uncinate fasciculus; white matter integrity; major depressive disorder; dynamic causal modeling; effective connectivity

Summary Background Disturbances in emotion regulation are the hallmarks of major depressive disorder (MDD). The incapacity to control negative emotion in patients has been associated with abnormal hyperactivation of the limbic system and hypoactivation of the frontal cortex. The amygdala and orbital...