Hydrogen sulfide‐loaded microbubbles combined with ultrasound mediate thrombolysis and simultaneously mitigate ischemia‐reperfusion injury in a rat hindlimb model

• Published in: Journal of thrombosis and haemostasis Vol. 19; no. 3; pp. 738 - 752
• Main Authors: Zhong, Jiayuan, Sun, Yili, Han, Yuan, Chen, Xiaoqiang, Li, Hairui, Ma, Yusheng, Lai, Yanxian, Wei, Guoquan, He, Xiang, Li, Mengsha, Liao, Wangjun, Liao, Yulin, Cao, Shiping, Bin, Jianping
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.03.2021; John Wiley and Sons Inc
• Subjects: AKT protein; Animals; Apoptosis; Blood flow; Caspase; Endothelial Cells; Flow velocity; Hemodynamics; Hindlimb; Hydrogen Sulfide; Hypoxia; Ischemia; ischemia/reperfusion injury; Macrophages; Microbubbles; Musculoskeletal system; Original; Perfusion; Phosphorylation; Rats; Reactive oxygen species; Reperfusion; Reperfusion Injury; Skeletal muscle; Thromboembolism; Thrombolysis; Thrombolytic drugs; Thrombolytic Therapy; THROMBOSIS; Ultrasonic imaging; Ultrasound; thrombolysis; microbubbles; hydrogen sulfide; ischemia/reperfusion injury; ultrasound

Background Thromboembolism and subsequent ischemia/reperfusion injury (IRI) remain major clinical challenges. Objectives To investigate whether hydrogen sulfide (H2S)‐loaded microbubbles (hs‐Mbs) combined with ultrasound (US) radiation (hs‐Mbs+US) dissolve thrombi and simultaneously alleviate tissue...