Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non‐native ligands

• Published in: Molecular microbiology Vol. 108; no. 3; pp. 240 - 257
• Main Authors: Wysoczynski‐Horita, Christina L., Boursier, Michelle E., Hill, Ryan, Hansen, Kirk, Blackwell, Helen E., Churchill, Mair E. A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2018
• Subjects: Bacterial Proteins - agonists; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - metabolism; Binding; Deoxyribonucleic acid; Detection; Dimerization; DNA; Gene expression; Ligands; Opportunist infection; Protein Binding; Pseudomonas aeruginosa; Pseudomonas aeruginosa - genetics; Quorum Sensing - physiology; Repressor Proteins - agonists; Repressor Proteins - antagonists & inhibitors; Repressor Proteins - metabolism; RhlR protein; Signal reception; Signal Transduction; Trans-Activators - metabolism; Transcription factors; Transcription Factors - metabolism; Virulence; Virulence - genetics

Summary Pseudomonas aeruginosa is an opportunistic pathogen that uses the process of quorum sensing (QS) to coordinate the expression of many virulence genes. During quorum sensing, N‐acyl‐homoserine lactone (AHL) signaling molecules regulate the activity of three LuxR‐type transcription factors, La...