Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study

• Published in: Movement disorders Vol. 37; no. 11; pp. 2289 - 2295
• Main Authors: Golfrè Andreasi, Nico, Cilia, Roberto, Romito, Luigi Michele, Bonvegna, Salvatore, Straccia, Giulia, Elia, Antonio Emanuele, Novelli, Alessio, Messina, Giuseppe, Tringali, Giovanni, Levi, Vincenzo, Devigili, Grazia, Rinaldo, Sara, Gasparini, Valentina, Grisoli, Marina, Stanziano, Mario, Ghielmetti, Francesco, Prioni, Sara, Bocchi, Elisa, Amami, Paolo, Piacentini, Sylvie Hélène Marie Jeanne, Ciceri, Elisa Francesca Maria, Bruzzone, Maria Grazia, Eleopra, Roberto
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2022; Wiley Subscription Services, Inc
• Subjects: Amine oxidase (flavin-containing); Brief Report; Brief Reports; Dopamine receptors; Essential Tremor - drug therapy; Essential Tremor - surgery; Humans; Levodopa; Levodopa - therapeutic use; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy; Movement disorders; MRgFUS; Neurodegenerative diseases; Parkinson Disease - drug therapy; Parkinson Disease - surgery; Parkinson's disease; Patients; Pilot Projects; thalamotomy; Thalamus - diagnostic imaging; Thalamus - surgery; Treatment Outcome; Tremor; Tremor (Muscular contraction); Tremor - drug therapy; Tremor - etiology; Tremor - surgery; Ultrasonic imaging; Ultrasound; VIM; thalamotomy; tremor; MRgFUS; Parkinson's disease; VIM

ABSTRACT Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). Objective The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐d...