Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study

ABSTRACT Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). Objective The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐d...

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Published inMovement disorders Vol. 37; no. 11; pp. 2289 - 2295
Main Authors Golfrè Andreasi, Nico, Cilia, Roberto, Romito, Luigi Michele, Bonvegna, Salvatore, Straccia, Giulia, Elia, Antonio Emanuele, Novelli, Alessio, Messina, Giuseppe, Tringali, Giovanni, Levi, Vincenzo, Devigili, Grazia, Rinaldo, Sara, Gasparini, Valentina, Grisoli, Marina, Stanziano, Mario, Ghielmetti, Francesco, Prioni, Sara, Bocchi, Elisa, Amami, Paolo, Piacentini, Sylvie Hélène Marie Jeanne, Ciceri, Elisa Francesca Maria, Bruzzone, Maria Grazia, Eleopra, Roberto
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.11.2022
Wiley Subscription Services, Inc
Subjects
Amine oxidase (flavin-containing)
Brief Report
Brief Reports
Dopamine receptors
Essential Tremor - drug therapy
Essential Tremor - surgery
Humans
Levodopa
Levodopa - therapeutic use
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
Movement disorders
MRgFUS
Neurodegenerative diseases
Parkinson Disease - drug therapy
Parkinson Disease - surgery
Parkinson's disease
Patients
Pilot Projects
thalamotomy
Thalamus - diagnostic imaging
Thalamus - surgery
Treatment Outcome
Tremor
Tremor (Muscular contraction)
Tremor - drug therapy
Tremor - etiology
Tremor - surgery
Ultrasonic imaging
Ultrasound
VIM
thalamotomy
tremor
MRgFUS
Parkinson's disease
VIM
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Abstract ABSTRACT Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). Objective The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy. Methods We prospectively enrolled patients with early‐stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD‐FUS) and patients treated with oral dopaminergic therapy (PD‐ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy. Results We included 10 patients in the PD‐FUS group and 20 patients in the PD‐ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD‐ODT group 6 months after thalamotomy. Conclusions In early‐stage tremor‐dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
AbstractList Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD). The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy. We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy. We included 10 patients in the PD-FUS group and 20 patients in the PD-ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD-ODT group 6 months after thalamotomy. In early-stage tremor-dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).BACKGROUNDMagnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.OBJECTIVEThe aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.METHODSWe prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.We included 10 patients in the PD-FUS group and 20 patients in the PD-ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD-ODT group 6 months after thalamotomy.RESULTSWe included 10 patients in the PD-FUS group and 20 patients in the PD-ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD-ODT group 6 months after thalamotomy.In early-stage tremor-dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.CONCLUSIONSIn early-stage tremor-dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
ABSTRACT Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). Objective The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy. Methods We prospectively enrolled patients with early‐stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD‐FUS) and patients treated with oral dopaminergic therapy (PD‐ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy. Results We included 10 patients in the PD‐FUS group and 20 patients in the PD‐ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD‐ODT group 6 months after thalamotomy. Conclusions In early‐stage tremor‐dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
BackgroundMagnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD).ObjectiveThe aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.MethodsWe prospectively enrolled patients with early‐stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD‐FUS) and patients treated with oral dopaminergic therapy (PD‐ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.ResultsWe included 10 patients in the PD‐FUS group and 20 patients in the PD‐ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD‐ODT group 6 months after thalamotomy.ConclusionsIn early‐stage tremor‐dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Author Golfrè Andreasi, Nico
Prioni, Sara
Bonvegna, Salvatore
Grisoli, Marina
Bruzzone, Maria Grazia
Ciceri, Elisa Francesca Maria
Rinaldo, Sara
Amami, Paolo
Novelli, Alessio
Piacentini, Sylvie Hélène Marie Jeanne
Stanziano, Mario
Messina, Giuseppe
Gasparini, Valentina
Ghielmetti, Francesco
Bocchi, Elisa
Levi, Vincenzo
Devigili, Grazia
Eleopra, Roberto
Elia, Antonio Emanuele
Cilia, Roberto
Tringali, Giovanni
Romito, Luigi Michele
Straccia, Giulia
AuthorAffiliation 6 Fondazione IRCCS Istituto Neurologico Carlo Besta Clinical Neuropsychology Unit Milan Italy
4 Neuroscience Department "Rita Levi Montalcini" University of Turin Turin Italy
7 Fondazione IRCCS Istituto Neurologico Carlo Besta Diagnostic Radiology and Interventional Neuroradiology Milan Italy
5 Fondazione IRCCS Istituto Neurologico Carlo Besta Health Department Milan Italy
3 Fondazione IRCCS Istituto Neurologico Carlo Besta Neuroradiology Unit Milan Italy
1 Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences Parkinson and Movement Disorders Unit Milan Italy
2 Fondazione IRCCS Istituto Neurologico Carlo Besta, Neurosurgery Department Functional Neurosurgery Unit Milan Italy
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Cites_doi 10.1002/mds.23429
10.1001/jamaneurol.2017.3098
10.3233/jpd-212810
10.1212/wnl.0000000000010316
10.1002/mds.21770
10.1056/nejmoa1205158
10.2169/internalmedicine.9586-17
10.1001/jamaneurol.2013.6233
10.1016/j.parkreldis.2011.11.001
10.2165/00002018-200932060-00004
10.2176/nmc.39.350
10.1002/mds.27228
10.1016/s0140-6736(14)60683-8
10.1002/mdc3.13223
10.3171/2016.10.JNS16758
10.1056/nejmoa060281
10.1212/wnl.0000000000005903
10.1093/brain/awaa181
10.1002/mds.27700
10.3171/2017.11.focus17614
10.1155/2015/219149
10.1016/j.parkreldis.2014.03.019
10.2176/nmc.oa.2020-0370
10.1002/mdc3.12921
10.1002/mds.22340
10.1002/mds.26712
10.1002/mds.27372
10.1212/wnl.17.5.427
10.1093/brain/awu195
10.1002/mds.27637
10.1056/nejmoa1600159
10.1002/mds.27348
10.1212/wnl.0000000000004268
10.1007/s10143-019-01216-y
ContentType Journal Article
Copyright 2022 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Copyright_xml – notice: 2022 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
– notice: 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
– notice: 2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 11
Keywords thalamotomy
tremor
MRgFUS
Parkinson's disease
VIM
Language English
License Attribution
2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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References 2021; 8
2021; 44
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2020; 143
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References_xml – volume: 44
  start-page: 1
  issue: E7
  year: 2018
  end-page: 10
  article-title: Preliminary experience with a transcranial magnetic resonance–guided focused ultrasound surgery system integrated with a 1.5‐T MRI unit in a series of patients with essential tremor and Parkinson's disease
  publication-title: Neurosurg Focus
– volume: 33
  start-page: 848
  year: 2018
  end-page: 849
  article-title: Magnetic resonance imaging–guided focused ultrasound Thalamotomy in Parkinson tremor: reoperation after benefit decay
  publication-title: Mov Disord
– volume: 32
  start-page: 475
  year: 2009
  end-page: 488
  article-title: Behavioural adverse effects of dopaminergic treatments in Parkinson's disease
  publication-title: Drug Saf
– volume: 384
  start-page: 1196
  year: 2014
  end-page: 1205
  article-title: Long‐term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open‐label, pragmatic randomised trial
  publication-title: Lancet
– volume: 18
  start-page: 268
  year: 2012
  end-page: 273
  article-title: Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trial
  publication-title: Parkinsonism Relat Disord
– volume: 34
  start-page: 950
  year: 2019
  end-page: 958
  article-title: MDS evidence‐based review of treatments for essential tremor
  publication-title: Mov Disord
– volume: 91
  start-page: e463
  year: 2018
  end-page: e471
  article-title: Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease
  publication-title: Neurology
– volume: 375
  start-page: 730
  year: 2016
  end-page: 739
  article-title: A randomized trial of focused ultrasound Thalamotomy for essential tremor
  publication-title: N Engl J Med
– volume: 2015
  start-page: 1
  year: 2015
  end-page: 4
  article-title: MRI guided focused ultrasound Thalamotomy for moderate‐to‐severe tremor in Parkinson's disease
  publication-title: Parkinson's Dis
– volume: 7
  start-page: 343
  year: 2020
  end-page: 345
  article-title: Levodopa equivalent dose conversion factors: an updated proposal including Opicapone and safinamide
  publication-title: Mov Disord Clin Pract
– volume: 12
  start-page: 199
  issue: 1
  year: 2022
  end-page: 206
  article-title: Focused ultrasound Thalamotomy in tremor dominant Parkinson's disease: long‐term results
  publication-title: J Parkinsons Dis
– volume: 44
  start-page: 115
  year: 2021
  end-page: 127
  article-title: Safety and efficacy of magnetic resonance imaging‐guided focused ultrasound neurosurgery for Parkinson's disease: a systematic review
  publication-title: Neurosurg Rev
– volume: 23
  start-page: 2129
  year: 2008
  end-page: 2170
  article-title: Movement Disorder Society‐sponsored revision of the unified Parkinson's disease rating scale (MDS‐UPDRS): scale presentation and clinimetric testing results
  publication-title: Mov Disord
– volume: 368
  start-page: 610
  year: 2013
  end-page: 622
  article-title: Neurostimulation for Parkinson's disease with early motor complications
  publication-title: N Engl J Med
– volume: 355
  start-page: 896
  year: 2006
  end-page: 908
  article-title: A randomized trial of deep‐brain stimulation for Parkinson's disease
  publication-title: N Engl J Med
– volume: 137
  start-page: 2731
  year: 2014
  end-page: 2742
  article-title: The modern pre‐levodopa era of Parkinson's disease: insights into motor complications from sub‐Saharan Africa
  publication-title: Brain
– volume: 17
  start-page: 427
  year: 1967
  end-page: 427
  article-title: Parkinsonism onset, progression, and mortality
  publication-title: Neurology
– volume: 61
  start-page: 414
  year: 2021
  end-page: 421
  article-title: Focused ultrasound Thalamotomy for tremor‐dominant Parkinson's disease: a prospective 1‐year follow‐up study
  publication-title: Neurol Med
– volume: 8
  start-page: 681
  year: 2021
  end-page: 687
  article-title: The role of focused ultrasound in the Management of Movement Disorders: insights after 5 years of experience
  publication-title: Mov Disord Clin Pract
– volume: 57
  start-page: 9586
  year: 2017
  end-page: 9517
  article-title: Magnetic resonance imaging‐guided focused ultrasound Thalamotomy for Parkinson's disease: a case report
  publication-title: Intern Med
– volume: 39
  start-page: 350
  year: 1999
  end-page: 357
  article-title: Long‐term results of ventrolateral Thalamotomy for patients with Parkinson's disease
  publication-title: Neurol Med
– volume: 33
  start-page: 36
  year: 2018
  end-page: 47
  article-title: The changing landscape of surgery for Parkinson's disease
  publication-title: Mov Disord
– volume: 95
  start-page: e1461
  year: 2020
  end-page: e1470
  article-title: Dopamine‐responsive and dopamine‐resistant resting tremor in Parkinson disease
  publication-title: Neurology
– volume: 128
  start-page: 202
  issue: 1
  year: 2018
  end-page: 210
  article-title: Magnetic resonance–guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson's disease and essential tremor cases
  publication-title: J Neurosurg
– volume: 33
  start-page: 1248
  issue: 8
  year: 2018
  end-page: 1266
  article-title: International Parkinson and movement disorder society evidence‐based medicine review: update on treatments for the motor symptoms of Parkinson's disease
  publication-title: Mov Disord
– volume: 89
  start-page: 771
  year: 2017
  end-page: 775
  article-title: MRI‐guided focused ultrasound thalamotomy in non‐ET tremor syndromes
  publication-title: Neurology
– volume: 20
  start-page: 731
  year: 2014
  end-page: 737
  article-title: Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease
  publication-title: Parkinsonism Relat Disord
– volume: 74
  start-page: 1412
  year: 2017
  end-page: 1418
  article-title: Safety and efficacy of focused ultrasound Thalamotomy for patients with medication‐refractory, tremor‐dominant Parkinson disease: a randomized clinical trial
  publication-title: JAMA Neurol
– volume: 71
  start-page: 499
  year: 2014
  end-page: 504
  article-title: Parkinson disease subtypes
  publication-title: JAMA Neurol
– volume: 25
  start-page: 2649
  year: 2010
  end-page: 2653
  article-title: Systematic review of levodopa dose equivalency reporting in Parkinson's disease
  publication-title: Mov Disord
– volume: 34
  start-page: 727
  year: 2019
  end-page: 734
  article-title: Four‐year follow‐up results of magnetic resonance‐guided focused ultrasound thalamotomy for essential tremor
  publication-title: Mov Disord
– volume: 23
  start-page: 75
  year: 2008
  end-page: 80
  article-title: Long‐term follow‐up of impulse control disorders in Parkinson's disease
  publication-title: Mov Disord
– volume: 143
  start-page: 2490
  issue: 8
  year: 2020
  end-page: 2501
  article-title: Natural history of motor symptoms in Parkinson's disease and the long‐duration response to levodopa
  publication-title: Brain
– volume: 31
  start-page: 1602
  year: 2016
  end-page: 1609
  article-title: Unmasking levodopa resistance in Parkinson's disease
  publication-title: Mov Disord
– ident: e_1_2_11_27_1
  doi: 10.1002/mds.23429
– ident: e_1_2_11_7_1
  doi: 10.1001/jamaneurol.2017.3098
– ident: e_1_2_11_14_1
  doi: 10.3233/jpd-212810
– ident: e_1_2_11_16_1
  doi: 10.1212/wnl.0000000000010316
– ident: e_1_2_11_33_1
  doi: 10.1002/mds.21770
– ident: e_1_2_11_32_1
  doi: 10.1056/nejmoa1205158
– ident: e_1_2_11_9_1
  doi: 10.2169/internalmedicine.9586-17
– ident: e_1_2_11_23_1
  doi: 10.1001/jamaneurol.2013.6233
– ident: e_1_2_11_22_1
  doi: 10.1016/j.parkreldis.2011.11.001
– ident: e_1_2_11_18_1
  doi: 10.2165/00002018-200932060-00004
– ident: e_1_2_11_29_1
  doi: 10.2176/nmc.39.350
– ident: e_1_2_11_3_1
  doi: 10.1002/mds.27228
– ident: e_1_2_11_34_1
  doi: 10.1016/s0140-6736(14)60683-8
– ident: e_1_2_11_4_1
  doi: 10.1002/mdc3.13223
– ident: e_1_2_11_10_1
  doi: 10.3171/2016.10.JNS16758
– ident: e_1_2_11_31_1
  doi: 10.1056/nejmoa060281
– ident: e_1_2_11_30_1
  doi: 10.1212/wnl.0000000000005903
– ident: e_1_2_11_35_1
  doi: 10.1093/brain/awaa181
– ident: e_1_2_11_2_1
  doi: 10.1002/mds.27700
– ident: e_1_2_11_11_1
  doi: 10.3171/2017.11.focus17614
– ident: e_1_2_11_28_1
  doi: 10.1155/2015/219149
– ident: e_1_2_11_24_1
  doi: 10.1016/j.parkreldis.2014.03.019
– ident: e_1_2_11_15_1
  doi: 10.2176/nmc.oa.2020-0370
– ident: e_1_2_11_21_1
  doi: 10.1002/mdc3.12921
– ident: e_1_2_11_25_1
  doi: 10.1002/mds.22340
– ident: e_1_2_11_17_1
  doi: 10.1002/mds.26712
– ident: e_1_2_11_19_1
  doi: 10.1002/mds.27372
– ident: e_1_2_11_26_1
  doi: 10.1212/wnl.17.5.427
– ident: e_1_2_11_20_1
  doi: 10.1093/brain/awu195
– ident: e_1_2_11_6_1
  doi: 10.1002/mds.27637
– ident: e_1_2_11_5_1
  doi: 10.1056/nejmoa1600159
– ident: e_1_2_11_12_1
  doi: 10.1002/mds.27348
– ident: e_1_2_11_13_1
  doi: 10.1212/wnl.0000000000004268
– ident: e_1_2_11_8_1
  doi: 10.1007/s10143-019-01216-y
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Snippet ABSTRACT Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in...
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD). The...
BackgroundMagnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease...
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease...
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SubjectTerms Amine oxidase (flavin-containing)
Brief Report
Brief Reports
Dopamine receptors
Essential Tremor - drug therapy
Essential Tremor - surgery
Humans
Levodopa
Levodopa - therapeutic use
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
Movement disorders
MRgFUS
Neurodegenerative diseases
Parkinson Disease - drug therapy
Parkinson Disease - surgery
Parkinson's disease
Patients
Pilot Projects
thalamotomy
Thalamus - diagnostic imaging
Thalamus - surgery
Treatment Outcome
Tremor
Tremor (Muscular contraction)
Tremor - drug therapy
Tremor - etiology
Tremor - surgery
Ultrasonic imaging
Ultrasound
VIM
Title Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.29200
https://www.ncbi.nlm.nih.gov/pubmed/36036203
https://www.proquest.com/docview/2735810025
https://www.proquest.com/docview/2707874696
https://pubmed.ncbi.nlm.nih.gov/PMC9804690
Volume 37
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