Metaplastic carcinomas of the breast without evidence of epithelial differentiation: a diagnostic approach for management

• Published in: Histopathology Vol. 78; no. 5; pp. 759 - 771
• Main Authors: Rakha, Emad A, Quinn, Cecily M, Foschini, Maria Pia, Muñoz Martin, Monica, Dabbs, David J, Lakhani, Sunil, Varga, Zsuzsanna, Pinder, Sarah E, Schmitt, Fernando C, Reis‐Filho, Jorge S, Fox, Stephen B, Ellis, Ian O, Tan, Puay‐Hoon, Mihai, Raluca
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2021
• Subjects: Adult; Biomarkers, Tumor - analysis; Breast - pathology; Breast cancer; Breast carcinoma; Breast metaplastic carcinoma; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Carcinoma, Intraductal, Noninfiltrating - diagnosis; Carcinoma, Intraductal, Noninfiltrating - pathology; CKs negative; Cohort Studies; diagnosis; Diagnosis, Differential; Epithelium - pathology; Female; Humans; Immunohistochemistry; Invasiveness; Keratins - analysis; Management; Middle Aged; Morphology; Retrospective Studies; Sarcoma; Sarcoma - diagnosis; Sarcoma - pathology; Tumors; Breast metaplastic carcinoma; diagnosis; CKs negative

Aims Although rare, malignant sarcomatoid breast tumours without evidence of epithelial differentiation comprise a diagnostic challenge with management implications. Earlier studies have generally considered these to be primary breast sarcomas; however, supporting evidence is lacking and management...