Connexin43 Contributes to Inflammasome Activation and Lipopolysaccharide-Initiated Acute Renal Injury via Modulation of Intracellular Oxidative Status

• Published in: Antioxidants & redox signaling Vol. 31; no. 16; p. 1194
• Main Authors: Huang, Yanru, Mao, Zhimin, Zhang, Zhen, Obata, Fumiko, Yang, Xiawen, Zhang, Xiling, Huang, Yong, Mitsui, Takahiko, Fan, Jianglin, Takeda, Masayuki, Yao, Jian
• Format: Journal Article
• Language: English
• Published: United States 01.12.2019
• Subjects: macrophage; acute kidney injury; gap junction; connexin43; inflammasome; oxidative stress

Inflammasome activation plays a pivotal role in many inflammatory diseases. Given that connexin (Cx) channels regulate numerous cellular events leading to inflammasome activation, we determined whether and how connexin affected inflammasome activation and inflammatory cell injury. Exposure of mouse...