Immunosenescence, aging and successful aging

Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immu...

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Published inFrontiers in immunology Vol. 13; p. 942796
Main Authors Wang, Yunan, Dong, Chen, Han, Yudian, Gu, Zhifeng, Sun, Chi
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 02.08.2022
Subjects
age-related diseases
centenarian
Immunology
immunosenescence
inflammation
successful aging
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Summary:Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.
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Edited by: Ke Rui, Affiliated Hospital of Jiangsu University, China
These authors have contributed equally to this work and share first authorship
Reviewed by: Yolanda María Pacheco, Institute of Biomedicine of Seville, Spanish National Research Council (CSIC), Spain; Weikan Wang, University of North Texas Health Science Center, United States
This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.942796