Immunosenescence, aging and successful aging

Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immu...

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Published inFrontiers in immunology Vol. 13; p. 942796
Main Authors Wang, Yunan, Dong, Chen, Han, Yudian, Gu, Zhifeng, Sun, Chi
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 02.08.2022
Subjects
age-related diseases
centenarian
Immunology
immunosenescence
inflammation
successful aging
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Abstract Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.
AbstractList Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.
Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.
Author Gu, Zhifeng
Wang, Yunan
Dong, Chen
Han, Yudian
Sun, Chi
AuthorAffiliation 2 Department of Rheumatology, Affiliated Hospital of Nantong University , Nantong , China
4 Department of Geriatrics, Affiliated Hospital of Nantong University , Nantong , China
3 Information Center, The First People’s Hospital of Nantong City , Nantong , China
1 Department of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University , Nantong , China
AuthorAffiliation_xml – name: 2 Department of Rheumatology, Affiliated Hospital of Nantong University , Nantong , China
– name: 1 Department of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University , Nantong , China
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– name: 4 Department of Geriatrics, Affiliated Hospital of Nantong University , Nantong , China
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Edited by: Ke Rui, Affiliated Hospital of Jiangsu University, China
These authors have contributed equally to this work and share first authorship
Reviewed by: Yolanda María Pacheco, Institute of Biomedicine of Seville, Spanish National Research Council (CSIC), Spain; Weikan Wang, University of North Texas Health Science Center, United States
This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology
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Snippet Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially...
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SubjectTerms age-related diseases
centenarian
Immunology
immunosenescence
inflammation
successful aging
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Title Immunosenescence, aging and successful aging
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