β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows

• Published in: Frontiers in veterinary science Vol. 9; p. 925900
• Main Authors: Dong, Zhihao, Sun, Xudong, Tang, Yan, Luo, Shengbin, Jia, Hongdou, Xu, Qiushi, Jiang, Qianming, Loor, Juan J., Xu, Wei, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 29.08.2022
• Subjects: ketosis; monocytes; oxidative stress; phagocytosis; Veterinary Science; β-hydroxybutyric acid

Cows with ketosis display severe metabolic stress and immune dysfunction which renders them more susceptible to infections. Monocytes, one of the major subtypes of white blood cells, play an important role in innate immune defense against infections. Thus, the aim of this study was to investigate al...