Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 117; no. 5; p. 1222
• Main Authors: Shah, V, Toruner, M, Haddad, F, Cadelina, G, Papapetropoulos, A, Choo, K, Sessa, W C, Groszmann, R J
• Format: Journal Article
• Language: English
• Published: United States 01.11.1999
• Subjects: Animals; Calmodulin - metabolism; Caveolin 1; Caveolins; In Vitro Techniques; Liver - enzymology; Liver Circulation - physiology; Liver Cirrhosis, Experimental - metabolism; Male; Membrane Proteins - metabolism; Nitric Oxide - biosynthesis; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type III; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Reference Values; Tissue Distribution

A reduction in nitric oxide (NO) has been implicated as a cause of intrahepatic vasoconstriction in cirrhosis, but the regulatory mechanisms remain undefined. The aim of this study was to examine a contributory role for caveolin-1, a putative negative regulator of endothelial NO synthase, in mediati...