Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain

• Published in: Frontiers in immunology Vol. 13; p. 890298
• Main Authors: Gargano, Francesca, Guerrera, Gisella, Piras, Eleonora, Serafini, Barbara, Di Paola, Monica, Rizzetto, Lisa, Buscarinu, Maria Chiara, Annibali, Viviana, Vuotto, Claudia, De Bardi, Marco, D’Orso, Silvia, Ruggieri, Serena, Gasperini, Claudio, Pavarini, Lorenzo, Ristori, Giovanni, Picozza, Mario, Rosicarelli, Barbara, Ballerini, Clara, Mechelli, Rosella, Vitali, Francesco, Cavalieri, Duccio, Salvetti, Marco, Angelini, Daniela F., Borsellino, Giovanna, De Filippo, Carlotta, Battistini, Luca
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 28.07.2022
• Subjects: dysbiosis; Immunology; MAIT cells; multiple sclerosis; mycobiome; neuroinflammation

The composition of the intestinal microbiota plays a critical role in shaping the immune system. Modern lifestyle, the inappropriate use of antibiotics, and exposure to pollution have significantly affected the composition of commensal microorganisms. The intestinal microbiota has been shown to sust...