Early Transcriptional Responses of HepG2-A16 Liver Cells to Infection by Plasmodium falciparum Sporozoites

• Published in: The Journal of biological chemistry Vol. 286; no. 30; pp. 26396 - 26405
• Main Authors: Chattopadhyay, Rana, de la Vega, Patricia, Paik, Sun H., Murata, Yoko, Ferguson, Earl W., Richie, Thomas L., Ooi, Guck T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.07.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genomics and Proteomics; Hep G2 Cells; Hepatocytes - metabolism; Hepatocytes - parasitology; HepG2-A16; Humans; Liver; Liver Cells; Malaria; Malaria, Falciparum - metabolism; Microarray; Parasite; Plasmodium falciparum; Sporozoites; Transcription; Transcription, Genetic; Liver Cells; Plasmodium falciparum; Gene Expression; Transcription; Malaria; Liver; Sporozoites; Parasite; HepG2-A16; Microarray

Invasion of hepatocytes by Plasmodium sporozoites deposited by Anopheles mosquitoes, and their subsequent transformation into infective merozoites is an obligatory step in the initiation of malaria. Interactions between the sporozoites and hepatocytes lead to a distinct, complex and coordinated cell...