A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors

• Published in: Pharmaceutical research Vol. 38; no. 4; pp. 669 - 680
• Main Authors: Wang, Yeying, Li, Qilong, Zhou, Jing-e, Tan, Jingwen, Li, Minghao, Xu, Nan, Qu, Feng, Chen, Jian, Li, Ji, Wang, Jing, Liang, Zhiqiang, Yu, Lei, Wang, Yiting, Yan, Zhiqiang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Cancer; Chemotherapy; Confocal microscopy; Cytotoxicity; Drug delivery; Drug delivery systems; Drugs; Ethylene glycol; Evaporation; Flow cytometry; Hyaluronic acid; Hydrogels; Medical Law; Nanoparticles; Paclitaxel; Pharmacology/Toxicology; Pharmacy; Polyethylene glycol; Polylactide-co-glycolide; Polymers; Research Paper; Tumors; Vehicles; in situ photopolymerization; semi-interpenetrating polymer networks hydrogel; local drug delivery; PEGDA-HA/PLGA-PTX

Purpose To address the issue of local drug delivery in tumor treatment, a novel nanoparticle-hydrogel superstructure, namely semi-interpenetrating polymer networks (semi-IPNs) hydrogel composed of poly (ethylene glycol) diacrylate (PEGDA) and hyaluronic acid (HA) and incorporated with paclitaxel (PT...