Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs

• Published in: Cellular oncology (Dordrecht) Vol. 35; no. 2; pp. 85 - 93
• Main Authors: Chacko, Alex D., McDade, Simon S., Chanduloy, Severine, Church, Stewart W., Kennedy, Richard, Price, John, Hall, Peter A., Russell, S. E. Hilary
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2012
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Line, Tumor; DNA Damage; Drug Resistance, Neoplasm - drug effects; Flow Cytometry; Humans; Ice; Microtubules - drug effects; Microtubules - metabolism; Oncology; Original Paper; Paclitaxel - pharmacology; Pathology; Polymerization - drug effects; Protein Isoforms - metabolism; Septins - metabolism; Vinblastine - analogs & derivatives; Vinblastine - pharmacology; Vinorelbine; SEPT9; Drug resistance; Septin; Microtubules

Background The evolutionarily conserved septin family of genes encode GTP binding proteins involved in a variety of cellular functions including cytokinesis, apoptosis, membrane dynamics and vesicle trafficking. Septin proteins can form hetero-oligomeric complexes and interact with other proteins in...