An update on advanced therapies for Parkinson's disease: From gene therapy to neuromodulation

• Published in: Frontiers in surgery Vol. 9; p. 863921
• Main Authors: Serva, Stephanie N., Bernstein, Jacob, Thompson, John A., Kern, Drew S., Ojemann, Steven G.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 23.09.2022
• Subjects: advanced therapies; deep brain stimulation; focused ultrasound; gene therapy; movement disorders; Parkinson's disease; Surgery

Advanced Parkinson's disease (PD) is characterized by increasingly debilitating impaired movements that include motor fluctuations and dyskinesias. At this stage of the disease, pharmacological management can result in unsatisfactory clinical benefits and increase the occurrence of adverse effe...