Keratin 1 maintains the intestinal barrier in ulcerative colitis

• Published in: Genes & genomics Vol. 43; no. 12; pp. 1389 - 1402
• Main Authors: Wu, Jing, Niu, Junkun, Li, Maojuan, Miao, Yinglei
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.12.2021; Springer Nature B.V; 한국유전학회
• Subjects: Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; Colitis, Ulcerative - metabolism; colon; Dextran; Dextran sulfate; Female; genetically modified organisms; genomics; Human Genetics; Humans; Immunohistochemistry; Inflammation; Inflammatory bowel disease; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Keratin; Keratin-1 - genetics; Keratin-1 - metabolism; Life Sciences; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Microbial Genetics and Genomics; Mucosa; occludins; pathogenesis; Plant Genetics and Genomics; Research Article; Spleen; tight junctions; Transcription; Transgenic mice; Ulcerative colitis; Western blotting; Zonula occludens-1 protein; 생물학; Intestinal barrier; Tight junction; Keratin 1; Ulcerative colitis

Background The intestinal mechanical barrier plays a key role in the pathogenesis of ulcerative colitis (UC). Our previous study showed keratin 1 (KRT1) was downregulated in UC, but the mechanism by which KRT1 affects the intestinal barrier remains unknown. Objectives To explore the mechanism of KRT...