Respiratory Syncytial Virus (RSV) Infects CD4⁺ T Cells: Frequency of Circulating CD4⁺ RSV⁺ T Cells as a Marker of Disease Severity in Young Children

• Published in: The Journal of infectious diseases Vol. 215; no. 7; pp. 1049 - 1058
• Main Authors: Raiden, Silvina, Sananez, Inés, Remes-Lenicov, Federico, Pandolfi, Julieta, Romero, Cecilia, De Lillo, Leonardo, Ceballos, Ana, Geffner, Jorge, Arruvito, Lourdes
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.04.2017
• Subjects: Adult; Biomarkers - blood; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - virology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Cell Line; Female; Fetal Blood - cytology; Flow Cytometry; Humans; Infant; Infant, Newborn; Interferon-gamma - immunology; Interleukin-2 - immunology; Major; Male; PATHOGENESIS AND HOST RESPONSE; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus, Human; CD4; viral infection; infants; interleukin 2; interferon γ; T cells; respiratory syncytial virus; markers of disease severity; bronchiolitis; CD4+ T cells

Background. Although human airway epithelial cells are the main target of respiratory syncytial virus (RSV), it also infects immune cells, such as macrophages and B cells. Whether T cells are permissive to RSV infection is unknown. We sought to analyze the permissiveness of CD4⁺ T cells to RSV infec...