Ezrin–Radixin–Moesin Binding Phosphoprotein 50: A Potential Novel Biomarker in Human Papilloma Virus-Associated Head and Neck Squamous Cell Carcinomas

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 13; no. 2; pp. 188 - 197
• Main Authors: Shankar, Athiva, Crouch, Dorothy H., Macluskey, Michaelina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2019
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Dentistry; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Oral and Maxillofacial Surgery; Original Paper; Otorhinolaryngology; Papillomavirus Infections - complications; Papillomavirus Infections - diagnosis; Pathology; Phosphoproteins - analysis; Phosphoproteins - biosynthesis; Retrospective Studies; Sodium-Hydrogen Exchangers - analysis; Sodium-Hydrogen Exchangers - biosynthesis; Squamous Cell Carcinoma of Head and Neck - diagnosis; Squamous Cell Carcinoma of Head and Neck - virology; Oropharyngeal cancers; Head and neck squamous cell carcinoma; Human papilloma virus; EBP50

High-risk human papilloma virus (HR-HPV) has increasingly been associated with head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal cancers. Ezrin–Radixin–Moesin Binding Phosphoprotein 50 (EBP50), a putative tumour suppressor, localises to the plasma membrane in suprabasal epit...