CATERPILLER 16.2 (CLR16.2), a Novel NBD/LRR Family Member That Negatively Regulates T Cell Function

• Published in: The Journal of biological chemistry Vol. 280; no. 18; pp. 18375 - 18385
• Main Authors: Conti, Brian J., Davis, Beckley K., Zhang, Jinghua, O'Connor, William, Williams, Kristi L., Ting, Jenny P.-Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.05.2005; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Carrier Proteins - genetics; Carrier Proteins - metabolism; Carrier Proteins - physiology; Cloning, Molecular; Down-Regulation - immunology; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - isolation & purification; Intercellular Signaling Peptides and Proteins - physiology; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Jurkat Cells; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membrane Proteins - physiology; Molecular Sequence Data; Multigene Family; Nod2 Signaling Adaptor Protein; Oligonucleotide Array Sequence Analysis; Peptide Fragments - genetics; Peptide Fragments - metabolism; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - physiology; T-Lymphocytes - metabolism; T-Lymphocytes - physiology

The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a...