CATERPILLER 16.2 (CLR16.2), a Novel NBD/LRR Family Member That Negatively Regulates T Cell Function
The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a...
Saved in:
Published in | The Journal of biological chemistry Vol. 280; no. 18; pp. 18375 - 18385 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
06.05.2005
American Society for Biochemistry and Molecular Biology |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. Analysis of CLR16.2 suggests the highest expression among T lymphocytes. Cellular localization studies of CLR16.2 revealed that it is a cytoplasmic protein. Querying microarray studies in the public data base showed that CLR16.2 was significantly (>90%) down-regulated 6 h after anti-CD3 and anti-CD28 stimulation of primary T lymphocytes. Its reduction upon T cell stimulation is consistent with a potential negative regulatory role. Indeed CLR16.2 decreased NF-κB, NFAT, and AP-1 induction of reporter gene constructs in response to T cell activation by anti-CD3 and anti-CD28 antibodies or PMA and ionomycin. Following T cell stimulation, the presence of CLR16.2 reduced the levels of the endogenous transcripts for the IL-2 and CD25 proteins that are central in maintaining T cell activation and preventing T cell anergy. This reduction was accompanied by a delay of IκBα degradation. We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. |
---|---|
AbstractList | The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. Analysis of CLR16.2 suggests the highest expression among T lymphocytes. Cellular localization studies of CLR16.2 revealed that it is a cytoplasmic protein. Querying microarray studies in the public data base showed that CLR16.2 was significantly (>90%) down-regulated 6 h after anti-CD3 and anti-CD28 stimulation of primary T lymphocytes. Its reduction upon T cell stimulation is consistent with a potential negative regulatory role. Indeed CLR16.2 decreased NF-kappaB, NFAT, and AP-1 induction of reporter gene constructs in response to T cell activation by anti-CD3 and anti-CD28 antibodies or PMA and ionomycin. Following T cell stimulation, the presence of CLR16.2 reduced the levels of the endogenous transcripts for the IL-2 and CD25 proteins that are central in maintaining T cell activation and preventing T cell anergy. This reduction was accompanied by a delay of IkappaBalpha degradation. We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. Analysis of CLR16.2 suggests the highest expression among T lymphocytes. Cellular localization studies of CLR16.2 revealed that it is a cytoplasmic protein. Querying microarray studies in the public data base showed that CLR16.2 was significantly (>90%) down-regulated 6 h after anti-CD3 and anti-CD28 stimulation of primary T lymphocytes. Its reduction upon T cell stimulation is consistent with a potential negative regulatory role. Indeed CLR16.2 decreased NF- Kappa B, NFAT, and AP-1 induction of reporter gene constructs in response to T cell activation by anti-CD3 and anti-CD28 antibodies or PMA and ionomycin. Following T cell stimulation, the presence of CLR16.2 reduced the levels of the endogenous transcripts for the IL-2 and CD25 proteins that are central in maintaining T cell activation and preventing T cell anergy. This reduction was accompanied by a delay of I Kappa B alpha degradation. We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. Analysis of CLR16.2 suggests the highest expression among T lymphocytes. Cellular localization studies of CLR16.2 revealed that it is a cytoplasmic protein. Querying microarray studies in the public data base showed that CLR16.2 was significantly (>90%) down-regulated 6 h after anti-CD3 and anti-CD28 stimulation of primary T lymphocytes. Its reduction upon T cell stimulation is consistent with a potential negative regulatory role. Indeed CLR16.2 decreased NF-κB, NFAT, and AP-1 induction of reporter gene constructs in response to T cell activation by anti-CD3 and anti-CD28 antibodies or PMA and ionomycin. Following T cell stimulation, the presence of CLR16.2 reduced the levels of the endogenous transcripts for the IL-2 and CD25 proteins that are central in maintaining T cell activation and preventing T cell anergy. This reduction was accompanied by a delay of IκBα degradation. We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R) proteins and are predicted to mediate important immune regulatory function. This report describes the first cloning and characterization of a novel CATERPILLER gene, CLR16.2 that is located on human chromosome 16. The protein encoded by this gene has a typical NBD-LRR configuration. Analysis of CLR16.2 suggests the highest expression among T lymphocytes. Cellular localization studies of CLR16.2 revealed that it is a cytoplasmic protein. Querying microarray studies in the public data base showed that CLR16.2 was significantly (>90%) down-regulated 6 h after anti-CD3 and anti-CD28 stimulation of primary T lymphocytes. Its reduction upon T cell stimulation is consistent with a potential negative regulatory role. Indeed CLR16.2 decreased NF-κB, NFAT, and AP-1 induction of reporter gene constructs in response to T cell activation by anti-CD3 and anti-CD28 antibodies or PMA and ionomycin. Following T cell stimulation, the presence of CLR16.2 reduced the levels of the endogenous transcripts for the IL-2 and CD25 proteins that are central in maintaining T cell activation and preventing T cell anergy. This reduction was accompanied by a delay of IκBα degradation. We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. |
Author | Zhang, Jinghua O'Connor, William Davis, Beckley K. Williams, Kristi L. Ting, Jenny P.-Y. Conti, Brian J. |
Author_xml | – sequence: 1 givenname: Brian J. surname: Conti fullname: Conti, Brian J. organization: Departments of Biochemistry and Biophysics and – sequence: 2 givenname: Beckley K. surname: Davis fullname: Davis, Beckley K. organization: Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 – sequence: 3 givenname: Jinghua surname: Zhang fullname: Zhang, Jinghua organization: Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 – sequence: 4 givenname: William surname: O'Connor fullname: O'Connor, William organization: Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 – sequence: 5 givenname: Kristi L. surname: Williams fullname: Williams, Kristi L. organization: Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 – sequence: 6 givenname: Jenny P.-Y. surname: Ting fullname: Ting, Jenny P.-Y. email: panyun@med.unc.edu organization: Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15705585$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkM1L5DAYh8Piso4f1z1KDiIK2zFpkiY9ap1xhTpKmYW9hTZ9OxPphzatMv-9GWbA07IhkBye9_f-eI7QQdu1gNBPSqaUSH79UpjpI6eMRnFIyDc0oUSxgAn69wBNCAlpEIdCHaIj516IPzymP9AhFZIIocQEmeRmOcueH9J0lmEaTUN8maTZ9nP1C-d40b1DjRe3d9dpluF53th6gx-hKaDHy3U-4AWs8sF6aIMzWI11PoDDS5xAXeP52JrBdu0J-l7ltYPT_XuM_sxny-R3kD7dPyQ3aWA4D4cAijiCKpa-MKtoZCQljFBiOPAwIpHiFVQlKxSUlEPJYhFLRTxLuCSlUQU7Rhe73Ne-exvBDbqxzvgmeQvd6HQkpeIRD_8LUimYFPEWnO5A03fO9VDp1942eb_RlOitf-396y__fuBsnzwWDZRf-F64B853wNqu1h-2B13Yzqyh0aHykcpfv9pjaoeB9_VuodfOWGgNlH7EDLrs7L8qfAKSDJtY |
CitedBy_id | crossref_primary_10_1099_jgv_0_000401 crossref_primary_10_1038_s41598_017_15629_6 crossref_primary_10_1038_s41423_021_00780_y crossref_primary_10_1016_j_yexcr_2018_04_018 crossref_primary_10_1038_cmi_2017_14 crossref_primary_10_5812_gct_118882 crossref_primary_10_1016_j_cytogfr_2014_07_001 crossref_primary_10_1038_ni_2228 crossref_primary_10_1016_j_beha_2008_03_003 crossref_primary_10_1007_s00011_018_1132_0 crossref_primary_10_3109_08830185_2013_777065 crossref_primary_10_1096_fj_201901764R crossref_primary_10_3390_biom12071005 crossref_primary_10_1016_j_molimm_2022_11_014 crossref_primary_10_3389_fimmu_2014_00169 crossref_primary_10_1124_pr_112_006171 crossref_primary_10_3389_fimmu_2019_02644 crossref_primary_10_1371_journal_pone_0145420 crossref_primary_10_1007_s00011_024_01905_5 crossref_primary_10_1038_nature20597 crossref_primary_10_3389_fimmu_2022_1012459 crossref_primary_10_1016_j_micinf_2013_03_008 crossref_primary_10_1016_j_dci_2022_104395 crossref_primary_10_1038_ni_2378 crossref_primary_10_1016_j_intimp_2024_112347 crossref_primary_10_1152_physrev_00009_2014 crossref_primary_10_1016_j_fsi_2016_01_029 crossref_primary_10_1038_s41598_019_44854_4 crossref_primary_10_1128_ecosalplus_8_8_3 crossref_primary_10_1186_s12864_023_09785_5 crossref_primary_10_3389_fimmu_2021_749646 crossref_primary_10_1016_j_humimm_2012_01_010 crossref_primary_10_1016_j_immuni_2024_03_012 crossref_primary_10_1128_IAI_00898_10 crossref_primary_10_1016_j_mib_2013_04_003 crossref_primary_10_1016_j_smim_2012_01_001 crossref_primary_10_3390_cells7090119 crossref_primary_10_1016_j_dci_2023_105078 crossref_primary_10_3390_ijms18071530 crossref_primary_10_1371_journal_pone_0030612 crossref_primary_10_1371_journal_ppat_1007266 crossref_primary_10_1016_j_dci_2010_09_011 crossref_primary_10_1016_j_dci_2020_103769 crossref_primary_10_1016_j_fsi_2012_06_033 crossref_primary_10_3349_ymj_2016_57_1_5 crossref_primary_10_1016_j_bj_2023_100616 crossref_primary_10_1002_jmv_29504 crossref_primary_10_1074_jbc_M111_333146 crossref_primary_10_4049_jimmunol_178_3_1256 crossref_primary_10_1158_1078_0432_CCR_10_2879 crossref_primary_10_1016_j_micinf_2007_01_018 crossref_primary_10_1016_j_bbrc_2005_10_074 crossref_primary_10_1159_000363602 crossref_primary_10_2174_1381612829666230330105320 crossref_primary_10_1016_j_hbpd_2020_04_003 crossref_primary_10_1016_j_immuni_2019_02_009 crossref_primary_10_1038_ni_1985 crossref_primary_10_1016_j_fsi_2016_06_029 crossref_primary_10_1371_journal_pone_0030344 crossref_primary_10_4049_jimmunol_0900779 crossref_primary_10_1074_jbc_M502820200 crossref_primary_10_1016_j_fsi_2017_12_012 crossref_primary_10_1074_jbc_M604638200 crossref_primary_10_3390_ijms222413397 crossref_primary_10_1016_j_ymthe_2022_08_023 crossref_primary_10_1016_j_fsirep_2021_100042 crossref_primary_10_4049_jimmunol_1601370 crossref_primary_10_1097_BCR_0b013e318159a41e crossref_primary_10_1016_j_fsi_2017_02_018 crossref_primary_10_1016_j_immuni_2018_10_008 crossref_primary_10_1002_glia_22499 crossref_primary_10_1111_mec_13520 crossref_primary_10_1002_jcp_29763 crossref_primary_10_3892_ijmm_2017_3077 crossref_primary_10_3390_ijms241914511 crossref_primary_10_1016_j_fsi_2023_108697 crossref_primary_10_1002_JLB_3MIR0817_346RRR crossref_primary_10_1073_pnas_1314923110 crossref_primary_10_1080_15384101_2017_1317414 crossref_primary_10_1016_j_fsi_2022_06_026 crossref_primary_10_4049_jimmunol_0903900 crossref_primary_10_1093_jxb_eraa532 crossref_primary_10_3390_pathogens2020232 crossref_primary_10_1146_annurev_pathol_4_110807_092239 crossref_primary_10_1038_nri1788 crossref_primary_10_1016_j_jot_2017_05_004 crossref_primary_10_1016_j_dci_2020_103859 crossref_primary_10_1016_j_humimm_2010_10_012 crossref_primary_10_1016_j_dci_2011_03_015 crossref_primary_10_1038_s41577_023_00849_x crossref_primary_10_1038_jcbfm_2013_227 crossref_primary_10_1155_2020_5328031 crossref_primary_10_1074_jbc_M116_769695 crossref_primary_10_1038_s41467_023_44251_6 crossref_primary_10_1002_jcp_28255 crossref_primary_10_1074_jbc_M110_109736 crossref_primary_10_1071_RD12409 crossref_primary_10_1371_journal_pone_0060842 crossref_primary_10_15252_embj_2018101397 crossref_primary_10_1189_jlb_0607402 crossref_primary_10_1007_s00436_015_4357_7 crossref_primary_10_1016_j_bbadis_2022_166518 crossref_primary_10_1097_MIB_0000000000000151 crossref_primary_10_1016_j_immuni_2018_12_003 crossref_primary_10_4161_viru_25180 crossref_primary_10_1016_j_scitotenv_2010_03_040 crossref_primary_10_3389_fimmu_2017_02012 crossref_primary_10_1038_sj_gene_6364454 |
Cites_doi | 10.1038/366751a0 10.1074/jbc.M203915200 10.4049/jimmunol.170.11.5354 10.1038/ng756 10.1038/ni0302-221 10.1016/S0014-5793(02)03416-6 10.1002/j.1460-2075.1982.tb01276.x 10.1016/S0092-8674(02)00703-1 10.1146/annurev.immunol.19.1.331 10.1073/pnas.012025199 10.1146/annurev.immunol.14.1.1 10.1016/S1369-5266(00)00081-9 10.1073/pnas.97.3.1014 10.1128/MCB.20.17.6185-6194.2000 10.1016/S0006-291X(03)00221-3 10.1016/j.ygeno.2004.06.013 10.1093/emboj/cdf321 10.1038/nri910 10.1074/jbc.M112208200 10.4049/jimmunol.167.7.3626 10.1038/35079114 10.1006/smim.1999.0192 10.1016/S0092-8674(05)80090-X 10.1016/S1097-2765(01)80010-1 10.1146/annurev.iy.04.040186.003113 10.1074/jbc.C200179200 10.1038/nri1086 10.1067/mai.2002.124965 10.1074/jbc.M008072200 10.1128/MCB.21.9.3001-3011.2001 10.1038/nrm1019 10.1038/ni0703-652 10.1016/S1359-6101(97)00021-X 10.1086/340786 10.1016/S0968-0004(00)01729-1 10.4049/jimmunol.171.12.6329 10.1074/jbc.274.48.33835 10.1002/art.10688 10.1038/nri1132 10.1016/S1074-5521(97)90257-X 10.1074/jbc.M307198200 10.1016/S1074-7613(01)00176-5 10.1006/excr.1998.4136 10.1073/pnas.092284399 10.4049/jimmunol.169.8.4088 10.1038/ng720 10.1074/jbc.274.21.14560 10.1073/pnas.231625398 10.1038/35079107 10.1016/S0167-5699(98)01379-6 10.1016/S1097-2765(02)00599-3 10.1186/1471-2105-4-37 10.1038/ni960 10.1073/pnas.0400782101 10.1016/S0092-8674(02)00696-7 10.1073/pnas.261567999 10.1126/science.1084677 10.1093/nar/gkg014 10.1126/science.278.5335.141 10.1038/ni945 10.1093/nar/gkg078 10.1016/S1369-5266(02)00265-0 10.1182/blood-2003-07-2531 10.1074/jbc.C200673200 10.1016/j.it.2003.10.007 10.1016/S1074-7613(04)00046-9 |
ContentType | Journal Article |
Copyright | 2005 © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
Copyright_xml | – notice: 2005 © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 8FD FR3 H94 P64 RC3 7X8 |
DOI | 10.1074/jbc.M413169200 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Genetics Abstracts Immunology Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
EISSN | 1083-351X |
EndPage | 18385 |
ExternalDocumentID | 10_1074_jbc_M413169200 15705585 280_18_18375 S0021925820657891 |
Genre | Research Support, U.S. Gov't, P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: PHS HHS grantid: 45580 – fundername: PHS HHS grantid: 41751 – fundername: NIDDK NIH HHS grantid: DK38108 – fundername: NIAID NIH HHS grantid: AI54309 – fundername: NIAID NIH HHS grantid: AI29564 – fundername: NINDS NIH HHS grantid: NS34910 |
GroupedDBID | --- -DZ -ET -~X .55 .GJ 0SF 186 18M 2WC 34G 39C 3O- 4.4 53G 5BI 5GY 5RE 5VS 6I. 79B 85S AAEDW AAFTH AAFWJ AARDX AAXUO ABDNZ ABOCM ABPPZ ABRJW ACGFO ACNCT ADBBV ADIYS ADNWM AENEX AEXQZ AFFNX AFMIJ AFOSN AFPKN AI. ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BTFSW C1A CJ0 CS3 DIK DU5 E3Z EBS EJD F20 F5P FA8 FDB FRP GROUPED_DOAJ GX1 HH5 HYE IH2 KQ8 L7B MVM N9A OHT OK1 P-O P0W P2P R.V RHF RHI RNS ROL RPM SJN TBC TN5 TR2 UHB UKR UPT UQL VH1 VQA W8F WH7 WHG WOQ X7M XFK XSW Y6R YQT YSK YWH YZZ ZA5 ZE2 ~02 ~KM - 02 55 AAWZA ABFLS ABPTK ABUFD ABZEH ADACO ADCOW AEILP AIZTS DL DZ ET FH7 GJ H13 KM LI MYA O0- X XHC 0R~ AALRI ADVLN AITUG AKRWK CGR CUY CVF ECM EIF NPM 29J 41~ 6TJ AAYJJ AAYOK AAYXX ABFSI ABTAH ACSFO ACYGS BAWUL CITATION E.L J5H NHB QZG XJT YYP ZGI ZY4 7T5 8FD FR3 H94 P64 RC3 7X8 |
ID | FETCH-LOGICAL-c442t-eb96ef979253f16c7103010c4e4260684fefd3b8ed14ed39597802530470dc8b3 |
ISSN | 0021-9258 |
IngestDate | Fri Oct 25 02:37:44 EDT 2024 Fri Oct 25 06:23:06 EDT 2024 Fri Dec 06 01:53:46 EST 2024 Sat Sep 28 08:40:09 EDT 2024 Tue Jan 05 14:52:05 EST 2021 Fri Feb 23 02:44:41 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 18 |
Language | English |
License | This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0 https://www.elsevier.com/tdm/userlicense/1.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c442t-eb96ef979253f16c7103010c4e4260684fefd3b8ed14ed39597802530470dc8b3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://dx.doi.org/10.1074/jbc.M413169200 |
PMID | 15705585 |
PQID | 17537592 |
PQPubID | 23462 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_67784642 proquest_miscellaneous_17537592 crossref_primary_10_1074_jbc_M413169200 pubmed_primary_15705585 highwire_biochem_280_18_18375 elsevier_sciencedirect_doi_10_1074_jbc_M413169200 |
ProviderPackageCode | RHF RHI |
PublicationCentury | 2000 |
PublicationDate | 2005-05-06 |
PublicationDateYYYYMMDD | 2005-05-06 |
PublicationDate_xml | – month: 05 year: 2005 text: 2005-05-06 day: 06 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of biological chemistry |
PublicationTitleAlternate | J Biol Chem |
PublicationYear | 2005 |
Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology |
Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology |
References | Walker, Saraste, Runswick, Gay (bib57) 1982; 1 Martinon, Burns, Tschopp (bib21) 2002; 10 Karin, Lin (bib63) 2002; 3 Girardin, Hugot, Sansonetti (bib38) 2003; 24 Bouma, Strober (bib37) 2003; 3 Weiss, Imboden, Hardy, Manger, Terhorst, Stobo (bib53) 1986; 4 Li, Spletter, Johnson (bib48) 2005 Harton, Linhoff, Zhang, Ting (bib3) 2002; 169 Pawlowski, Pio, Chu, Reed, Godzik (bib6) 2001; 26 Grenier, Wang, Manji, Huang, Al-Garawi, Kelly, Carlson, Merriam, Lora, Briskin, DiStefano, Bertin (bib16) 2002; 530 Beutler (bib36) 2001; 15 Su, Wiltshire, Batalov, Lapp, Ching, Block, Zhang, Soden, Hayakawa, Kreiman, Cooke, Walker, Hogenesch (bib40) 2004; 101 Huang, Kudo, Yoshida, Miyamoto (bib52) 2000; 97 Neven, Callebaut, Prieur, Feldmann, Bodemer, Lepore, Derfalvi, Benjaponpitak, Vesely, Sauvain, Oertle, Allen, Morgan, Borkhardt, Hill, Gardner-Medwin, Fischer, De Saint Basile (bib15) 2004; 103 Manji, Wang, Geddes, Brown, Merriam, Al-Garawi, Mak, Lora, Briskin, Jurman, Cao, DiStefano, Bertin (bib22) 2002; 277 Huang, Wang, Chen, Qian, Yeo, Bemis (bib47) 2004; 84 Chamaillard, Hashimoto, Horie, Masumoto, Qiu, Saab, Ogura, Kawasaki, Fukase, Kusumoto, Valvano, Foster, Mak, Nunez, Inohara (bib31) 2003; 4 Kobayashi, Eynon, Flavell (bib35) 2003; 4 Miceli-Richard, Lesage, Rybojad, Prieur, Manouvrier-Hanu, Hafner, Chamaillard, Zouali, Thomas, Hugot (bib28) 2001; 29 Ghosh, Karin (bib65) 2002; 109 Kobe, Deisenhofer (bib58) 1993; 366 Williams, Taxman, Linhoff, Reed, Ting (bib26) 2003; 170 Linhoff, Harton, Cressman, Martin, Ting (bib60) 2001; 21 Tschopp, Martinon, Burns (bib5) 2003; 4 Girardin, Boneca, Carneiro, Antignac, Jehanno, Viala, Tedin, Taha, Labigne, Zahringer, Coyle, DiStefano, Bertin, Sansonetti, Philpott (bib32) 2003; 300 Su, Cooke, Ching, Hakak, Walker, Wiltshire, Orth, Vega, Sapinoso, Moqrich, Patapoutian, Hampton, Schultz, Hogenesch (bib41) 2002; 99 Lin, Leonard (bib55) 1997; 8 Reith, Mach (bib10) 2001; 19 Diehn, Alizadeh, Rando, Liu, Stankunas, Botstein, Crabtree, Brown (bib43) 2002; 99 Hollander (bib54) 1999; 11 Hillig, Renault, Vetter, Drell, Wittinghofer, Becker (bib59) 1999; 3 Wang, Manji, Grenier, Al-Garawi, Merriam, Lora, Geddes, Briskin, DiStefano, Bertin (bib25) 2002; 277 Lord, Lechler, George (bib67) 1999; 20 Dode, Le Du, Cuisset, Letourneur, Berthelot, Vaudour, Meyrier, Watts, Scott, Nicholls, Granel, Frances, Garcier, Edery, Boulinguez, Domergues, Delpech, Grateau (bib13) 2002; 70 Harton, Ting (bib7) 2000; 20 Kim, Leonard (bib56) 2002; 21 Hugot, Chamaillard, Zouali, Lesage, Cezard, Belaiche, Almer, Tysk, O'Morain, Gassull, Binder, Finkel, Cortot, Modigliani, Laurent-Puig, Gower-Rousseau, Macry, Colombel, Sahbatou, Thomas (bib27) 2001; 411 Nel, Slaughter (bib66) 2002; 109 Srinivasula, Poyet, Razmara, Datta, Zhang, Alnemri (bib20) 2002; 277 Ting, Trowsdale (bib8) 2002; 109 Young (bib2) 2000; 3 Hoffman, Mueller, Broide, Wanderer, Kolodner (bib14) 2001; 29 Ogura, Inohara, Benito, Chen, Yamaoka, Nunez (bib62) 2001; 276 Wong, Brickey, Taxman, van Deventer, Reed, Gao, Zheng, Liu, Li, Blum, McKinnon, Ting (bib11) 2003; 4 Agostini, Martinon, Burns, McDermott, Hawkins, Tschopp (bib19) 2004; 20 Inohara, Ogura, Fontalba, Gutierrez, Pons, Crespo, Fukase, Inamura, Kusumoto, Hashimoto, Foster, Moran, Fernandez-Luna, Nunez (bib34) 2003; 278 Dowds, Masumoto, Chen, Ogura, Inohara, Nunez (bib23) 2003; 302 Ogura, Bonen, Inohara, Nicolae, Chen, Ramos, Britton, Moran, Karaliuskas, Duerr, Achkar, Brant, Bayless, Kirschner, Hanauer, Nunez, Cho (bib29) 2001; 411 Ossareh-Nazari, Bachelerie, Dargemont (bib51) 1997; 278 Inohara, Nunez (bib4) 2003; 3 Aksentijevich, Nowak, Mallah, Chae, Watford, Hofmann, Stein, Russo, Goldsmith, Dent, Rosenberg, Austin, Remmers, Balow, Rosenzweig, Komarow, Shoham, Wood, Jones, Mangra, Carrero, Adams, Moore, Schikler, Hoffman, Lovell, Lipnick, Barron, O'Shea, Kastner, Goldbach-Mansky (bib12) 2002; 46 Boldrick, Alizadeh, Diehn, Dudoit, Liu, Belcher, Botstein, Staudt, Brown, Relman (bib45) 2002; 99 Steimle, Otten, Zufferey, Mach (bib9) 1993; 75 Cressman, O'Connor, Greer, Zhu, Ting (bib39) 2001; 167 Nurnberger, Brunner (bib1) 2002; 5 Kudo, Wolff, Sekimoto, Schreiner, Yoneda, Yanagida, Horinouchi, Yoshida (bib50) 1998; 242 Masumoto, Taniguchi, Ayukawa, Sarvotham, Kishino, Niikawa, Hidaka, Katsuyama, Higuchi, Sagara (bib18) 1999; 274 Gollub, Ball, Binkley, Demeter, Finkelstein, Hebert, Hernandez-Boussard, Jin, Kaloper, Matese, Schroeder, Brown, Botstein, Sherlock (bib42) 2003; 31 Sloan-Lancaster, Allen (bib68) 1996; 14 Inohara, Koseki, del Peso, Hu, Yee, Chen, Carrio, Merino, Liu, Ni, Nunez (bib61) 1999; 274 Diehn, Sherlock, Binkley, Jin, Matese, Hernandez-Boussard, Rees, Cherry, Botstein, Brown, Alizadeh (bib44) 2003; 31 O'Connor, Harton, Zhu, Linhoff, Ting (bib24) 2003; 171 Li, Verma (bib64) 2002; 2 Dowds, Masumoto, Zhu, Inohara, Nunez (bib17) 2004 Wolff, Sanglier, Wang (bib49) 1997; 4 Galfalvy, Erraji-Benchekroun, Smyrniotopoulos, Pavlidis, Ellis, Mann, Sibille, Arango (bib46) 2003; 4 Hampe, Frenzel, Mirza, Croucher, Cuthbert, Mascheretti, Huse, Platzer, Bridger, Meyer, Nurnberg, Stokkers, Krawczak, Mathew, Curran, Schreiber (bib30) 2002; 99 Girardin, Travassos, Herve, Blanot, Boneca, Philpott, Sansonetti, Mengin-Lecreulx (bib33) 2003; 278 Hampe (10.1074/jbc.M413169200_bib30) 2002; 99 Diehn (10.1074/jbc.M413169200_bib44) 2003; 31 Li (10.1074/jbc.M413169200_bib48) 2005 Martinon (10.1074/jbc.M413169200_bib21) 2002; 10 Dowds (10.1074/jbc.M413169200_bib17) 2004 Williams (10.1074/jbc.M413169200_bib26) 2003; 170 Hollander (10.1074/jbc.M413169200_bib54) 1999; 11 Young (10.1074/jbc.M413169200_bib2) 2000; 3 Tschopp (10.1074/jbc.M413169200_bib5) 2003; 4 Kobe (10.1074/jbc.M413169200_bib58) 1993; 366 Hugot (10.1074/jbc.M413169200_bib27) 2001; 411 Boldrick (10.1074/jbc.M413169200_bib45) 2002; 99 Girardin (10.1074/jbc.M413169200_bib32) 2003; 300 Ogura (10.1074/jbc.M413169200_bib62) 2001; 276 Girardin (10.1074/jbc.M413169200_bib38) 2003; 24 Ghosh (10.1074/jbc.M413169200_bib65) 2002; 109 Galfalvy (10.1074/jbc.M413169200_bib46) 2003; 4 Steimle (10.1074/jbc.M413169200_bib9) 1993; 75 Hoffman (10.1074/jbc.M413169200_bib14) 2001; 29 Masumoto (10.1074/jbc.M413169200_bib18) 1999; 274 Harton (10.1074/jbc.M413169200_bib7) 2000; 20 Manji (10.1074/jbc.M413169200_bib22) 2002; 277 Dode (10.1074/jbc.M413169200_bib13) 2002; 70 Agostini (10.1074/jbc.M413169200_bib19) 2004; 20 Diehn (10.1074/jbc.M413169200_bib43) 2002; 99 Karin (10.1074/jbc.M413169200_bib63) 2002; 3 Huang (10.1074/jbc.M413169200_bib52) 2000; 97 Srinivasula (10.1074/jbc.M413169200_bib20) 2002; 277 Kobayashi (10.1074/jbc.M413169200_bib35) 2003; 4 Chamaillard (10.1074/jbc.M413169200_bib31) 2003; 4 Nel (10.1074/jbc.M413169200_bib66) 2002; 109 Su (10.1074/jbc.M413169200_bib41) 2002; 99 Inohara (10.1074/jbc.M413169200_bib4) 2003; 3 Wang (10.1074/jbc.M413169200_bib25) 2002; 277 Dowds (10.1074/jbc.M413169200_bib23) 2003; 302 Li (10.1074/jbc.M413169200_bib64) 2002; 2 Neven (10.1074/jbc.M413169200_bib15) 2004; 103 Inohara (10.1074/jbc.M413169200_bib61) 1999; 274 Hillig (10.1074/jbc.M413169200_bib59) 1999; 3 Wolff (10.1074/jbc.M413169200_bib49) 1997; 4 Sloan-Lancaster (10.1074/jbc.M413169200_bib68) 1996; 14 Reith (10.1074/jbc.M413169200_bib10) 2001; 19 Miceli-Richard (10.1074/jbc.M413169200_bib28) 2001; 29 Su (10.1074/jbc.M413169200_bib40) 2004; 101 Walker (10.1074/jbc.M413169200_bib57) 1982; 1 Ting (10.1074/jbc.M413169200_bib8) 2002; 109 O'Connor (10.1074/jbc.M413169200_bib24) 2003; 171 Aksentijevich (10.1074/jbc.M413169200_bib12) 2002; 46 Girardin (10.1074/jbc.M413169200_bib33) 2003; 278 Ossareh-Nazari (10.1074/jbc.M413169200_bib51) 1997; 278 Gollub (10.1074/jbc.M413169200_bib42) 2003; 31 Harton (10.1074/jbc.M413169200_bib3) 2002; 169 Kim (10.1074/jbc.M413169200_bib56) 2002; 21 Beutler (10.1074/jbc.M413169200_bib36) 2001; 15 Wong (10.1074/jbc.M413169200_bib11) 2003; 4 Nurnberger (10.1074/jbc.M413169200_bib1) 2002; 5 Ogura (10.1074/jbc.M413169200_bib29) 2001; 411 Grenier (10.1074/jbc.M413169200_bib16) 2002; 530 Cressman (10.1074/jbc.M413169200_bib39) 2001; 167 Linhoff (10.1074/jbc.M413169200_bib60) 2001; 21 Pawlowski (10.1074/jbc.M413169200_bib6) 2001; 26 Lin (10.1074/jbc.M413169200_bib55) 1997; 8 Kudo (10.1074/jbc.M413169200_bib50) 1998; 242 Lord (10.1074/jbc.M413169200_bib67) 1999; 20 Huang (10.1074/jbc.M413169200_bib47) 2004; 84 Weiss (10.1074/jbc.M413169200_bib53) 1986; 4 Inohara (10.1074/jbc.M413169200_bib34) 2003; 278 Bouma (10.1074/jbc.M413169200_bib37) 2003; 3 |
References_xml | – volume: 103 start-page: 2809 year: 2004 end-page: 2815 ident: bib15 publication-title: Blood contributor: fullname: De Saint Basile – volume: 10 start-page: 417 year: 2002 end-page: 426 ident: bib21 publication-title: Mol. Cell contributor: fullname: Tschopp – volume: 11 start-page: 357 year: 1999 end-page: 367 ident: bib54 publication-title: Semin. Immunol. contributor: fullname: Hollander – volume: 4 start-page: 652 year: 2003 end-page: 654 ident: bib35 publication-title: Nat. Immunol. contributor: fullname: Flavell – volume: 1 start-page: 945 year: 1982 end-page: 951 ident: bib57 publication-title: EMBO J. contributor: fullname: Gay – volume: 4 start-page: 37 year: 2003 ident: bib46 publication-title: BMC Bioinformatics contributor: fullname: Arango – volume: 5 start-page: 318 year: 2002 end-page: 324 ident: bib1 publication-title: Curr. Opin. Plant Biol. contributor: fullname: Brunner – volume: 99 start-page: 321 year: 2002 end-page: 326 ident: bib30 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Schreiber – volume: 20 start-page: 6185 year: 2000 end-page: 6194 ident: bib7 publication-title: Mol. Cell. Biol. contributor: fullname: Ting – volume: 109 start-page: S81 year: 2002 end-page: S96 ident: bib65 publication-title: Cell contributor: fullname: Karin – volume: 109 start-page: S21 year: 2002 end-page: S33 ident: bib8 publication-title: Cell contributor: fullname: Trowsdale – volume: 21 start-page: 3001 year: 2001 end-page: 3011 ident: bib60 publication-title: Mol. Cell. Biol. contributor: fullname: Ting – volume: 31 start-page: 219 year: 2003 end-page: 223 ident: bib44 publication-title: Nucleic Acids Res. contributor: fullname: Alizadeh – volume: 21 start-page: 3051 year: 2002 end-page: 3059 ident: bib56 publication-title: EMBO J. contributor: fullname: Leonard – volume: 4 start-page: 891 year: 2003 end-page: 898 ident: bib11 publication-title: Nat. Immunol. contributor: fullname: Ting – volume: 302 start-page: 575 year: 2003 end-page: 580 ident: bib23 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Nunez – volume: 99 start-page: 972 year: 2002 end-page: 977 ident: bib45 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Relman – volume: 274 start-page: 14560 year: 1999 end-page: 14567 ident: bib61 publication-title: J. Biol. Chem. contributor: fullname: Nunez – volume: 20 start-page: 319 year: 2004 end-page: 325 ident: bib19 publication-title: Immunity contributor: fullname: Tschopp – volume: 46 start-page: 3340 year: 2002 end-page: 3348 ident: bib12 publication-title: Arthritis Rheum. contributor: fullname: Goldbach-Mansky – volume: 19 start-page: 331 year: 2001 end-page: 373 ident: bib10 publication-title: Annu. Rev. Immunol. contributor: fullname: Mach – volume: 75 start-page: 135 year: 1993 end-page: 146 ident: bib9 publication-title: Cell contributor: fullname: Mach – volume: 97 start-page: 1014 year: 2000 end-page: 1019 ident: bib52 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Miyamoto – volume: 4 start-page: 593 year: 1986 end-page: 619 ident: bib53 publication-title: Annu. Rev. Immunol. contributor: fullname: Stobo – volume: 20 start-page: 33 year: 1999 end-page: 39 ident: bib67 publication-title: Immunol Today contributor: fullname: George – volume: 84 start-page: 767 year: 2004 end-page: 777 ident: bib47 publication-title: Genomics contributor: fullname: Bemis – volume: 277 start-page: 29874 year: 2002 end-page: 29880 ident: bib25 publication-title: J. Biol. Chem. contributor: fullname: Bertin – volume: 2 start-page: 725 year: 2002 end-page: 734 ident: bib64 publication-title: Nat. Rev. Immunol. contributor: fullname: Verma – volume: 4 start-page: 702 year: 2003 end-page: 707 ident: bib31 publication-title: Nat. Immunol. contributor: fullname: Inohara – volume: 171 start-page: 6329 year: 2003 end-page: 6333 ident: bib24 publication-title: J. Immunol. contributor: fullname: Ting – volume: 4 start-page: 139 year: 1997 end-page: 147 ident: bib49 publication-title: Chem. Biol. contributor: fullname: Wang – volume: 278 start-page: 5509 year: 2003 end-page: 5512 ident: bib34 publication-title: J. Biol. Chem. contributor: fullname: Nunez – volume: 278 start-page: 141 year: 1997 end-page: 144 ident: bib51 publication-title: Science contributor: fullname: Dargemont – volume: 170 start-page: 5354 year: 2003 end-page: 5358 ident: bib26 publication-title: J. Immunol. contributor: fullname: Ting – volume: 109 start-page: 901 year: 2002 end-page: 915 ident: bib66 publication-title: J. Allergy Clin. Immunol. contributor: fullname: Slaughter – volume: 4 start-page: 95 year: 2003 end-page: 104 ident: bib5 publication-title: Nat. Rev. Mol. Cell. Biol. contributor: fullname: Burns – volume: 366 start-page: 751 year: 1993 end-page: 756 ident: bib58 publication-title: Nature contributor: fullname: Deisenhofer – volume: 26 start-page: 85 year: 2001 end-page: 87 ident: bib6 publication-title: Trends Biochem. Sci. contributor: fullname: Godzik – volume: 167 start-page: 3626 year: 2001 end-page: 3634 ident: bib39 publication-title: J. Immunol. contributor: fullname: Ting – volume: 3 start-page: 781 year: 1999 end-page: 791 ident: bib59 publication-title: Mol. Cell contributor: fullname: Becker – volume: 29 start-page: 19 year: 2001 end-page: 20 ident: bib28 publication-title: Nat. Genet. contributor: fullname: Hugot – volume: 278 start-page: 41702 year: 2003 end-page: 41708 ident: bib33 publication-title: J. Biol. Chem. contributor: fullname: Mengin-Lecreulx – volume: 101 start-page: 6062 year: 2004 end-page: 6067 ident: bib40 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Hogenesch – year: 2004 ident: bib17 publication-title: J. Biol. Chem. contributor: fullname: Nunez – volume: 276 start-page: 4812 year: 2001 end-page: 4818 ident: bib62 publication-title: J. Biol. Chem. contributor: fullname: Nunez – volume: 3 start-page: 285 year: 2000 end-page: 290 ident: bib2 publication-title: Curr. Opin. Plant Biol. contributor: fullname: Young – volume: 530 start-page: 73 year: 2002 end-page: 78 ident: bib16 publication-title: FEBS Lett. contributor: fullname: Bertin – volume: 24 start-page: 652 year: 2003 end-page: 658 ident: bib38 publication-title: Trends Immunol. contributor: fullname: Sansonetti – volume: 274 start-page: 33835 year: 1999 end-page: 33838 ident: bib18 publication-title: J. Biol. Chem. contributor: fullname: Sagara – volume: 3 start-page: 221 year: 2002 end-page: 227 ident: bib63 publication-title: Nat. Immunol. contributor: fullname: Lin – volume: 277 start-page: 21119 year: 2002 end-page: 21122 ident: bib20 publication-title: J. Biol. Chem. contributor: fullname: Alnemri – volume: 411 start-page: 599 year: 2001 end-page: 603 ident: bib27 publication-title: Nature contributor: fullname: Thomas – year: 2005 ident: bib48 publication-title: Physiol. Genomics contributor: fullname: Johnson – volume: 242 start-page: 540 year: 1998 end-page: 547 ident: bib50 publication-title: Exp. Cell Res. contributor: fullname: Yoshida – volume: 29 start-page: 301 year: 2001 end-page: 305 ident: bib14 publication-title: Nat. Genet. contributor: fullname: Kolodner – volume: 411 start-page: 603 year: 2001 end-page: 606 ident: bib29 publication-title: Nature contributor: fullname: Cho – volume: 99 start-page: 4465 year: 2002 end-page: 4470 ident: bib41 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Hogenesch – volume: 99 start-page: 11796 year: 2002 end-page: 11801 ident: bib43 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Brown – volume: 14 start-page: 1 year: 1996 end-page: 27 ident: bib68 publication-title: Annu. Rev. Immunol. contributor: fullname: Allen – volume: 169 start-page: 4088 year: 2002 end-page: 4093 ident: bib3 publication-title: J. Immunol. contributor: fullname: Ting – volume: 15 start-page: 5 year: 2001 end-page: 14 ident: bib36 publication-title: Immunity contributor: fullname: Beutler – volume: 3 start-page: 371 year: 2003 end-page: 382 ident: bib4 publication-title: Nat. Rev. Immunol. contributor: fullname: Nunez – volume: 277 start-page: 11570 year: 2002 end-page: 11575 ident: bib22 publication-title: J. Biol. Chem. contributor: fullname: Bertin – volume: 8 start-page: 313 year: 1997 end-page: 332 ident: bib55 publication-title: Cytokine Growth Factor Rev. contributor: fullname: Leonard – volume: 31 start-page: 94 year: 2003 end-page: 96 ident: bib42 publication-title: Nucleic Acids Res. contributor: fullname: Sherlock – volume: 3 start-page: 521 year: 2003 end-page: 533 ident: bib37 publication-title: Nat. Rev. Immunol. contributor: fullname: Strober – volume: 300 start-page: 1584 year: 2003 end-page: 1587 ident: bib32 publication-title: Science contributor: fullname: Philpott – volume: 70 start-page: 1498 year: 2002 end-page: 1506 ident: bib13 publication-title: Am. J. Hum. Genet. contributor: fullname: Grateau – volume: 366 start-page: 751 year: 1993 ident: 10.1074/jbc.M413169200_bib58 publication-title: Nature doi: 10.1038/366751a0 contributor: fullname: Kobe – volume: 277 start-page: 29874 year: 2002 ident: 10.1074/jbc.M413169200_bib25 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M203915200 contributor: fullname: Wang – volume: 170 start-page: 5354 year: 2003 ident: 10.1074/jbc.M413169200_bib26 publication-title: J. Immunol. doi: 10.4049/jimmunol.170.11.5354 contributor: fullname: Williams – volume: 29 start-page: 301 year: 2001 ident: 10.1074/jbc.M413169200_bib14 publication-title: Nat. Genet. doi: 10.1038/ng756 contributor: fullname: Hoffman – volume: 3 start-page: 221 year: 2002 ident: 10.1074/jbc.M413169200_bib63 publication-title: Nat. Immunol. doi: 10.1038/ni0302-221 contributor: fullname: Karin – volume: 530 start-page: 73 year: 2002 ident: 10.1074/jbc.M413169200_bib16 publication-title: FEBS Lett. doi: 10.1016/S0014-5793(02)03416-6 contributor: fullname: Grenier – volume: 1 start-page: 945 year: 1982 ident: 10.1074/jbc.M413169200_bib57 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01276.x contributor: fullname: Walker – volume: 109 start-page: S81 year: 2002 ident: 10.1074/jbc.M413169200_bib65 publication-title: Cell doi: 10.1016/S0092-8674(02)00703-1 contributor: fullname: Ghosh – volume: 19 start-page: 331 year: 2001 ident: 10.1074/jbc.M413169200_bib10 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.19.1.331 contributor: fullname: Reith – volume: 99 start-page: 4465 year: 2002 ident: 10.1074/jbc.M413169200_bib41 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.012025199 contributor: fullname: Su – volume: 14 start-page: 1 year: 1996 ident: 10.1074/jbc.M413169200_bib68 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.14.1.1 contributor: fullname: Sloan-Lancaster – volume: 3 start-page: 285 year: 2000 ident: 10.1074/jbc.M413169200_bib2 publication-title: Curr. Opin. Plant Biol. doi: 10.1016/S1369-5266(00)00081-9 contributor: fullname: Young – volume: 97 start-page: 1014 year: 2000 ident: 10.1074/jbc.M413169200_bib52 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.97.3.1014 contributor: fullname: Huang – volume: 20 start-page: 6185 year: 2000 ident: 10.1074/jbc.M413169200_bib7 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.17.6185-6194.2000 contributor: fullname: Harton – volume: 302 start-page: 575 year: 2003 ident: 10.1074/jbc.M413169200_bib23 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(03)00221-3 contributor: fullname: Dowds – volume: 84 start-page: 767 year: 2004 ident: 10.1074/jbc.M413169200_bib47 publication-title: Genomics doi: 10.1016/j.ygeno.2004.06.013 contributor: fullname: Huang – volume: 21 start-page: 3051 year: 2002 ident: 10.1074/jbc.M413169200_bib56 publication-title: EMBO J. doi: 10.1093/emboj/cdf321 contributor: fullname: Kim – volume: 2 start-page: 725 year: 2002 ident: 10.1074/jbc.M413169200_bib64 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri910 contributor: fullname: Li – volume: 277 start-page: 11570 year: 2002 ident: 10.1074/jbc.M413169200_bib22 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112208200 contributor: fullname: Manji – volume: 167 start-page: 3626 year: 2001 ident: 10.1074/jbc.M413169200_bib39 publication-title: J. Immunol. doi: 10.4049/jimmunol.167.7.3626 contributor: fullname: Cressman – volume: 411 start-page: 603 year: 2001 ident: 10.1074/jbc.M413169200_bib29 publication-title: Nature doi: 10.1038/35079114 contributor: fullname: Ogura – volume: 11 start-page: 357 year: 1999 ident: 10.1074/jbc.M413169200_bib54 publication-title: Semin. Immunol. doi: 10.1006/smim.1999.0192 contributor: fullname: Hollander – volume: 75 start-page: 135 year: 1993 ident: 10.1074/jbc.M413169200_bib9 publication-title: Cell doi: 10.1016/S0092-8674(05)80090-X contributor: fullname: Steimle – volume: 3 start-page: 781 year: 1999 ident: 10.1074/jbc.M413169200_bib59 publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)80010-1 contributor: fullname: Hillig – volume: 4 start-page: 593 year: 1986 ident: 10.1074/jbc.M413169200_bib53 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.iy.04.040186.003113 contributor: fullname: Weiss – volume: 277 start-page: 21119 year: 2002 ident: 10.1074/jbc.M413169200_bib20 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C200179200 contributor: fullname: Srinivasula – volume: 3 start-page: 371 year: 2003 ident: 10.1074/jbc.M413169200_bib4 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1086 contributor: fullname: Inohara – volume: 109 start-page: 901 year: 2002 ident: 10.1074/jbc.M413169200_bib66 publication-title: J. Allergy Clin. Immunol. doi: 10.1067/mai.2002.124965 contributor: fullname: Nel – year: 2004 ident: 10.1074/jbc.M413169200_bib17 publication-title: J. Biol. Chem. contributor: fullname: Dowds – volume: 276 start-page: 4812 year: 2001 ident: 10.1074/jbc.M413169200_bib62 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M008072200 contributor: fullname: Ogura – year: 2005 ident: 10.1074/jbc.M413169200_bib48 publication-title: Physiol. Genomics contributor: fullname: Li – volume: 21 start-page: 3001 year: 2001 ident: 10.1074/jbc.M413169200_bib60 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.9.3001-3011.2001 contributor: fullname: Linhoff – volume: 4 start-page: 95 year: 2003 ident: 10.1074/jbc.M413169200_bib5 publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm1019 contributor: fullname: Tschopp – volume: 4 start-page: 652 year: 2003 ident: 10.1074/jbc.M413169200_bib35 publication-title: Nat. Immunol. doi: 10.1038/ni0703-652 contributor: fullname: Kobayashi – volume: 8 start-page: 313 year: 1997 ident: 10.1074/jbc.M413169200_bib55 publication-title: Cytokine Growth Factor Rev. doi: 10.1016/S1359-6101(97)00021-X contributor: fullname: Lin – volume: 70 start-page: 1498 year: 2002 ident: 10.1074/jbc.M413169200_bib13 publication-title: Am. J. Hum. Genet. doi: 10.1086/340786 contributor: fullname: Dode – volume: 26 start-page: 85 year: 2001 ident: 10.1074/jbc.M413169200_bib6 publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(00)01729-1 contributor: fullname: Pawlowski – volume: 171 start-page: 6329 year: 2003 ident: 10.1074/jbc.M413169200_bib24 publication-title: J. Immunol. doi: 10.4049/jimmunol.171.12.6329 contributor: fullname: O'Connor – volume: 274 start-page: 33835 year: 1999 ident: 10.1074/jbc.M413169200_bib18 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.48.33835 contributor: fullname: Masumoto – volume: 46 start-page: 3340 year: 2002 ident: 10.1074/jbc.M413169200_bib12 publication-title: Arthritis Rheum. doi: 10.1002/art.10688 contributor: fullname: Aksentijevich – volume: 3 start-page: 521 year: 2003 ident: 10.1074/jbc.M413169200_bib37 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1132 contributor: fullname: Bouma – volume: 4 start-page: 139 year: 1997 ident: 10.1074/jbc.M413169200_bib49 publication-title: Chem. Biol. doi: 10.1016/S1074-5521(97)90257-X contributor: fullname: Wolff – volume: 278 start-page: 41702 year: 2003 ident: 10.1074/jbc.M413169200_bib33 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M307198200 contributor: fullname: Girardin – volume: 15 start-page: 5 year: 2001 ident: 10.1074/jbc.M413169200_bib36 publication-title: Immunity doi: 10.1016/S1074-7613(01)00176-5 contributor: fullname: Beutler – volume: 242 start-page: 540 year: 1998 ident: 10.1074/jbc.M413169200_bib50 publication-title: Exp. Cell Res. doi: 10.1006/excr.1998.4136 contributor: fullname: Kudo – volume: 99 start-page: 11796 year: 2002 ident: 10.1074/jbc.M413169200_bib43 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.092284399 contributor: fullname: Diehn – volume: 169 start-page: 4088 year: 2002 ident: 10.1074/jbc.M413169200_bib3 publication-title: J. Immunol. doi: 10.4049/jimmunol.169.8.4088 contributor: fullname: Harton – volume: 29 start-page: 19 year: 2001 ident: 10.1074/jbc.M413169200_bib28 publication-title: Nat. Genet. doi: 10.1038/ng720 contributor: fullname: Miceli-Richard – volume: 274 start-page: 14560 year: 1999 ident: 10.1074/jbc.M413169200_bib61 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.21.14560 contributor: fullname: Inohara – volume: 99 start-page: 972 year: 2002 ident: 10.1074/jbc.M413169200_bib45 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.231625398 contributor: fullname: Boldrick – volume: 411 start-page: 599 year: 2001 ident: 10.1074/jbc.M413169200_bib27 publication-title: Nature doi: 10.1038/35079107 contributor: fullname: Hugot – volume: 20 start-page: 33 year: 1999 ident: 10.1074/jbc.M413169200_bib67 publication-title: Immunol Today doi: 10.1016/S0167-5699(98)01379-6 contributor: fullname: Lord – volume: 10 start-page: 417 year: 2002 ident: 10.1074/jbc.M413169200_bib21 publication-title: Mol. Cell doi: 10.1016/S1097-2765(02)00599-3 contributor: fullname: Martinon – volume: 4 start-page: 37 year: 2003 ident: 10.1074/jbc.M413169200_bib46 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-4-37 contributor: fullname: Galfalvy – volume: 4 start-page: 891 year: 2003 ident: 10.1074/jbc.M413169200_bib11 publication-title: Nat. Immunol. doi: 10.1038/ni960 contributor: fullname: Wong – volume: 101 start-page: 6062 year: 2004 ident: 10.1074/jbc.M413169200_bib40 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0400782101 contributor: fullname: Su – volume: 109 start-page: S21 year: 2002 ident: 10.1074/jbc.M413169200_bib8 publication-title: Cell doi: 10.1016/S0092-8674(02)00696-7 contributor: fullname: Ting – volume: 99 start-page: 321 year: 2002 ident: 10.1074/jbc.M413169200_bib30 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.261567999 contributor: fullname: Hampe – volume: 300 start-page: 1584 year: 2003 ident: 10.1074/jbc.M413169200_bib32 publication-title: Science doi: 10.1126/science.1084677 contributor: fullname: Girardin – volume: 31 start-page: 219 year: 2003 ident: 10.1074/jbc.M413169200_bib44 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg014 contributor: fullname: Diehn – volume: 278 start-page: 141 year: 1997 ident: 10.1074/jbc.M413169200_bib51 publication-title: Science doi: 10.1126/science.278.5335.141 contributor: fullname: Ossareh-Nazari – volume: 4 start-page: 702 year: 2003 ident: 10.1074/jbc.M413169200_bib31 publication-title: Nat. Immunol. doi: 10.1038/ni945 contributor: fullname: Chamaillard – volume: 31 start-page: 94 year: 2003 ident: 10.1074/jbc.M413169200_bib42 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg078 contributor: fullname: Gollub – volume: 5 start-page: 318 year: 2002 ident: 10.1074/jbc.M413169200_bib1 publication-title: Curr. Opin. Plant Biol. doi: 10.1016/S1369-5266(02)00265-0 contributor: fullname: Nurnberger – volume: 103 start-page: 2809 year: 2004 ident: 10.1074/jbc.M413169200_bib15 publication-title: Blood doi: 10.1182/blood-2003-07-2531 contributor: fullname: Neven – volume: 278 start-page: 5509 year: 2003 ident: 10.1074/jbc.M413169200_bib34 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C200673200 contributor: fullname: Inohara – volume: 24 start-page: 652 year: 2003 ident: 10.1074/jbc.M413169200_bib38 publication-title: Trends Immunol. doi: 10.1016/j.it.2003.10.007 contributor: fullname: Girardin – volume: 20 start-page: 319 year: 2004 ident: 10.1074/jbc.M413169200_bib19 publication-title: Immunity doi: 10.1016/S1074-7613(04)00046-9 contributor: fullname: Agostini |
SSID | ssj0000491 |
Score | 2.235862 |
Snippet | The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R)... The newly discovered mammalian CATERPILLER (NOD, NALP, PAN) family of proteins share similarities with the NBD-LRR superfamily of plant disease resistance (R)... |
SourceID | proquest crossref pubmed highwire elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 18375 |
SubjectTerms | Amino Acid Sequence Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Cloning, Molecular Down-Regulation - immunology HeLa Cells Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - isolation & purification Intercellular Signaling Peptides and Proteins - physiology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Jurkat Cells Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Molecular Sequence Data Multigene Family Nod2 Signaling Adaptor Protein Oligonucleotide Array Sequence Analysis Peptide Fragments - genetics Peptide Fragments - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - physiology T-Lymphocytes - metabolism T-Lymphocytes - physiology |
Title | CATERPILLER 16.2 (CLR16.2), a Novel NBD/LRR Family Member That Negatively Regulates T Cell Function |
URI | https://dx.doi.org/10.1074/jbc.M413169200 http://www.jbc.org/content/280/18/18375.abstract https://www.ncbi.nlm.nih.gov/pubmed/15705585 https://search.proquest.com/docview/17537592 https://search.proquest.com/docview/67784642 |
Volume | 280 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLaq8QAvCDYuBQZ-QFwU0uXiOMljWzZN3VpB1Ul7s3KxmdBI0ZYiwV_iT3KOHSctUAn2EqVpmrj5vvgcHx9_h5CXRRaqIohLN1KeclnuF27uydzlWaRClfFYlbg4eTrjx2dsch6d93o_17KWVnU-KH78dV3JTVCFY4ArrpL9D2Tbi8IB2Ad8YQsIw_afMB4PwRn9AOPxw7nj80Ggp2RP57gLI3ydmOnMlt_kpTMbvYfbnM7nttLFVGIlEGdxkdXQ0X3S8t-X6I_r0vTy2lk4YwzrHYHda7H73FFrzZE1Ok5GacSWj2unNpaVyRcYXWFPMhl0kfFG3WAk9eSyc9J-1cawJ2BWL1at3bB5OSbA0ASKNqIWkc4R5F0ozS6n2cj2NPkigdFyH0jTI4OPiMsNzte77MBUf7LcTNZ6YOiiTCmWxpzDZ1MT6A9bAc4T2oq8GEzBkvs8NZqpv-tv43S2j40KwFuLE1RKuIWqi1io4eRjJ00PQy1TnrH5D1YhNGYHm_fY5gG1AtXbBzva6VncI3cbkOnQUO8-6clql-wNq6xefvlOX1GdP6wnZnbJ7bEFf48Ua8ykSEf6puHl23c0o5qTFDh5AIykhpHUMJIiI2nHSNoyki4oMpJaRj4gZ0eHi_Gx25TzcAvGgtqVecqlSuHRRaHyeRFjhTvfK5jEKgk8YUqqMswTWfpMlmEaoTgWnOux2CuLJA8fkp1qWcnHhMZFmDFVwlg4zVmmoqyQXAHwAY-9zA94n7y2j1h8NaotQmdbxEwAGKIDo098i4BofE7jSwqgydbf7FuoBLxi-GoJYKTwE6HZ1ycvLH4CnjvOwGWVXK6uBcrixlEabD8D9RwZZ3DGIwN81_4Iha-S6MkNWvyU3AnAGTcpjs_ITn21kvvgTNf5c03iXzYevW8 |
link.rule.ids | 314,780,784,27924,27925 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CATERPILLER+16.2+%28CLR16.2%29%2C+a+Novel+NBD%2FLRR+Family+Member+That+Negatively+Regulates+T+Cell+Function&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Conti%2C+Brian+J.&rft.au=Davis%2C+Beckley+K.&rft.au=Zhang%2C+Jinghua&rft.au=O%27Connor%2C+William&rft.date=2005-05-06&rft.pub=Elsevier+Inc&rft.issn=0021-9258&rft.eissn=1083-351X&rft.volume=280&rft.issue=18&rft.spage=18375&rft.epage=18385&rft_id=info:doi/10.1074%2Fjbc.M413169200&rft.externalDocID=S0021925820657891 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon |