PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation

• Published in: Frontiers in physiology Vol. 13; p. 960480
• Main Authors: Sun, Mengjia, Chen, Zhen, Song, Yuanbin, Zhang, Bo, Yang, Jie, Tan, Hu
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 09.08.2022
• Subjects: atrial fibrillation; autophagy; calcium flux; endocardial endothelial cell; Physiology; PLXND1

Left atrial appendage (LAA) thrombus detachment resulting in intracranial embolism is a major complication of atrial fibrillation (AF). Endocardial endothelial cell (EEC) injury leads to thrombosis, whereas autophagy protects against EEC dysfunction. However, the role and underlying mechanisms of au...