A gene expression map of host immune response in human brucellosis

• Published in: Frontiers in immunology Vol. 13; p. 951232
• Main Authors: Mitroulis, Ioannis, Chrysanthopoulou, Akrivi, Divolis, Georgios, Ioannidis, Charalampos, Ntinopoulou, Maria, Tasis, Athanasios, Konstantinidis, Theocharis, Antoniadou, Christina, Soteriou, Natalia, Lallas, George, Mitka, Stella, Lesche, Mathias, Dahl, Andreas, Gembardt, Stephanie, Panopoulou, Maria, Sideras, Paschalis, Wielockx, Ben, Coskun, Ünal, Ritis, Konstantinos, Skendros, Panagiotis
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 01.08.2022
• Subjects: brucellosis; immunity; Immunology; macrophages; peripheral blood mononuclear cells; polymorphonuclear neutrophils; transcriptomics

Brucellosis is a common zoonotic disease caused by intracellular pathogens of the genus Brucella . Brucella infects macrophages and evades clearance mechanisms, thus resulting in chronic parasitism. Herein, we studied the molecular changes that take place in human brucellosis both in vitro and ex vi...