Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling

• Published in: The Journal of neuroscience Vol. 41; no. 17; pp. 3799 - 3807
• Main Authors: Zhang, Longbo, Lin, Tiffany V, Yuan, Qianying, Sadoul, Remy, Lam, TuKiet T, Bordey, Angélique
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 28.04.2021
• Subjects: Binding; Cytoplasm; Dendritic spines; Deoxyribonucleic acid; DNA; Extracellular vesicles; Gene regulation; HDAC2 protein; Histone deacetylase; Neurons; Signaling; Spine; Synapses; Synaptic density; Transcription activation; Vesicles; cortex; development; spine; synapse; exosome; HDAC

The release of small extracellular vesicles (sEVs) has recently been reported, but knowledge of their function in neuron development remains limited. Using LC-MS/MS, we found that sEVs released from developing cortical neurons obtained from mice of both sexes were enriched in cytoplasm, exosome, and...