Hindsiipropane B alleviates HIV-1 Tat-induced inflammatory responses by suppressing HDAC6-NADPH oxidase-ROS axis in astrocytes - Jo, Hyundong; Jang, Ha Young; Youn, Gi Soo; Kim, Donggyu; Lee, Chae Yeon; Jang, Jae Hee; Choi, Soo Young; Jun, Jong-Gab; Park, Jinseu (BMB reports, 2018)
Keywords: Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; Astrocytes - virology; Celastrus - chemistry; Cell Line; Chemokines - biosynthesis; Chemokines - immunology; Histone Deacetylase 6 - antagonists & inhibitors; Histone Deacetylase 6 - metabolism; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - metabolism; HIV-1 - metabolism; Humans; Inflammation - immunology; Inflammation - virology; MAP Kinase Signaling System - drug effects; NADPH Oxidases - antagonists & inhibitors; NADPH Oxidases - metabolism; NF-kappa B - metabolism; Plant Extracts - pharmacology; Propane - analogs & derivatives; Propane - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; tat Gene Products, Human Immunodeficiency Virus - immunology; tat Gene Products, Human Immunodeficiency Virus - metabolism; 화학