Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene

• Published in: Frontiers in genetics Vol. 13; p. 903971
• Main Authors: Clark, Karen C., Wagner, Valerie A., Holl, Katie L., Reho, John J., Tutaj, Monika, Smith, Jennifer R., Dwinell, Melinda R., Grobe, Justin L., Kwitek, Anne E.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.06.2022
• Subjects: body weight; congenic rat; fat distribution; Genetics; metabolism; QTL mapping; rat model

Central obesity is genetically complex, and its exponential increase in the last decades have made it a critical public health issue. The Lyon Hypertensive (LH) rat is a well-characterized hypertensive model that also exhibits spontaneous and profound differences in body weight and adiposity, relati...