A Small Vimentin-Binding Molecule Blocks Cancer Exosome Release and Reduces Cancer Cell Mobility

• Published in: Frontiers in pharmacology Vol. 12; p. 627394
• Main Authors: Wu, Jianping, Xie, Qian, Liu, Yanjun, Gao, Yanan, Qu, Zhipeng, Mo, Lian, Xu, Ying, Chen, Ruihuan, Shi, Liyun
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.07.2021
• Subjects: cancer mobility; exosomes; inhibitor; Pharmacology; small molecule; vimentin

Vimentin is an intermediate filament protein with diverse roles in health and disease far beyond its structural functions. Exosomes or small extracellular vesicles (sEVs) are key mediators for intercellular communication, contributing to tissue homeostasis and the progression of various diseases, es...