Antagonistic Serotonergic and Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior in Caenorhabditis elegans

• Published in: The Journal of neuroscience Vol. 37; no. 33; pp. 7811 - 7823
• Main Authors: Churgin, Matthew A, McCloskey, Richard J, Peters, Emily, Fang-Yen, Christopher
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 16.08.2017
• Subjects: Adaptability; Amines; Animals; Behavior; Biogenic amines; Caenorhabditis elegans; Caenorhabditis elegans Proteins - physiology; Circuits; Fasting; Feeding; Feeding behavior; Feeding Behavior - physiology; Food; Hermaphrodites; Locomotion - physiology; Locomotor activity; Metabolism; Muscles; Nematodes; Nerve Net - physiology; Neural networks; Neurons; Neurotransmitters; Octopamine; Octopamine - physiology; Receptors; Receptors, Serotonin - physiology; Serotonin; Serotonin - physiology; Signaling; Tryptophan Hydroxylase - physiology; octopamine; Caenorhabditis elegans; serotonin; behavioral states; 5-HT; locomotion

Biogenic amines are conserved signaling molecules that link food cues to behavior and metabolism in a wide variety of organisms. In the nematode , the biogenic amines serotonin (5-HT) and octopamine regulate a number of food-related behaviors. Using a novel method for long-term quantitative behavior...