Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling

• Published in: Frontiers in pharmacology Vol. 13; p. 940365
• Main Authors: Zhang, Jing, Cheng, Yun-Jiu, Luo, Chang-Jun, Yu, Jia
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 12.08.2022
• Subjects: (Pro)renin receptor; cardiac remodeling; endoplasmic reticulum stress; heart failure; Pharmacology; PRO20

Background: Ectopic activation of renin-angiotensin-system contributes to cardiovascular and renal diseases. (Pro)renin receptor (PRR) binds to renin and prorenin, participating in the progression of nephrology. However, whether PRR could be considered as a therapeutic target for cardiac remodeling...