The Last r Locus Unveiled: T4 RIII Is a Cytoplasmic Antiholin

• Published in: Journal of bacteriology Vol. 198; no. 18; pp. 2448 - 2457
• Main Authors: Chen, Yi, Young, Ry
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.09.2016
• Subjects: Amino acids; Bacterial proteins; Bacteriology; Bacteriophage T4 - physiology; Binding sites; Biochemistry; Cytoplasm; E coli; Escherichia coli; Escherichia coli - virology; Gene Deletion; Gene expression; Gene Expression Regulation, Viral - physiology; Mutation; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Release

The latent period of phage T4, normally ∼25 min, can be extended indefinitely if the infected cell is superinfected after 5 min. This phenomenon, designated lysis inhibition (LIN), was first described in the 1940s and is genetically defined by mutations in diverse T4 r genes. RI, the main effector o...