A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase - Atwell, Shane; Adams, Jason M.; Badger, John; Buchanan, Michelle D.; Feil, Ingeborg K.; Froning, Karen J.; Gao, Xia; Hendle, Jörg; Keegan, Kevin; Leon, Barbara C.; Müller-Dieckmann, Hans J.; Nienaber, Vicki L.; et al. (The Journal of biological chemistry, 2004)
Keywords: Animals; Benzamides; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Precursors - chemistry; Hematopoietic Stem Cells - metabolism; Humans; Hydrogen Bonding; Imatinib Mesylate; Insecta; Intracellular Signaling Peptides and Proteins; Ligands; Models, Molecular; Mutation; Phosphorylation; Piperazines - pharmacology; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein-Tyrosine Kinases - chemistry; Pyrimidines - pharmacology; Signal Transduction; Staurosporine - pharmacology; Syk Kinase; X-Rays