Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats

• Published in: Cardiovascular toxicology Vol. 21; no. 7; pp. 563 - 571
• Main Authors: Engin, Seckin, Yasar, Yesim Kaya, Barut, Elif Nur, Sezen, Sena F.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer; Springer Nature B.V
• Subjects: Animals; Antiparasitic agents; Aorta; Aorta, Thoracic - drug effects; Aorta, Thoracic - metabolism; Aorta, Thoracic - physiopathology; Biomedical and Life Sciences; Biomedicine; Blood; Blood sugar; Body weight; Carbachol; Cardiology; Cell Adhesion Molecules - metabolism; Complications; Cyclic GMP; Cyclic GMP - metabolism; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 1 - chemically induced; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - physiopathology; Diabetic Angiopathies - chemically induced; Diabetic Angiopathies - metabolism; Diabetic Angiopathies - physiopathology; Diabetic Angiopathies - prevention & control; Drug Repositioning; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Ethylenediaminetetraacetic acid; Glucose; Hyperglycemia; Male; Microfilament Proteins - metabolism; Niclosamide; Niclosamide - pharmacology; Nitric Oxide - metabolism; Nitric Oxide Synthase Type III - metabolism; Pharmacology/Toxicology; Phosphoproteins - metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Rodents; Serine; Streptozocin; Thorax; Type 1 diabetes; Vasodilation - drug effects; Vasodilators; Western blotting; Endothelial dysfunction; Niclosamide; Diabetes; Streptozotocin; Nitric oxide

Diabetes‐induced endothelial dysfunction is critical for the development of diabetic cardiovascular complications. The aim of this study was to investigate the effect of niclosamide (Nic) on vascular endothelial dysfunction in streptozotocin (STZ)-induced diabetic rats. Male Sprague–Dawley rats were...