Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inne...
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| Published in | Frontiers in cell and developmental biology Vol. 9; p. 679325 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
28.05.2021
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| Abstract | Meis
genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the
Meis2
gene during vertebrate inner ear induction and the formation of the cochlea.
Meis2
is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of
Meis2
in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of
Meis2
reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of
Meis2
in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from
Meis2
mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for
Meis2
which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that
Meis2
is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct. |
|---|---|
| AbstractList | Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct. Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct. Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct.Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct. |
| Author | Alonso, María Teresa Martin, Donna M. Durán Alonso, María Beatriz Schimmang, Thomas Carramolino, Laura Giovinazzo, Giovanna Torres, Miguel López-Hernández, Iris Vázquez, Enrique Vendrell, Victor Giráldez, Fernando |
| AuthorAffiliation | 3 CEXS, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona , Barcelona , Spain 1 Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas , Valladolid , Spain 2 Departments of Pediatrics and Human Genetics, University of Michigan , Ann Arbor, MI , United States 4 Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC , Madrid , Spain |
| AuthorAffiliation_xml | – name: 4 Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC , Madrid , Spain – name: 3 CEXS, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona , Barcelona , Spain – name: 1 Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas , Valladolid , Spain – name: 2 Departments of Pediatrics and Human Genetics, University of Michigan , Ann Arbor, MI , United States |
| Author_xml | – sequence: 1 givenname: María Beatriz surname: Durán Alonso fullname: Durán Alonso, María Beatriz – sequence: 2 givenname: Victor surname: Vendrell fullname: Vendrell, Victor – sequence: 3 givenname: Iris surname: López-Hernández fullname: López-Hernández, Iris – sequence: 4 givenname: María Teresa surname: Alonso fullname: Alonso, María Teresa – sequence: 5 givenname: Donna M. surname: Martin fullname: Martin, Donna M. – sequence: 6 givenname: Fernando surname: Giráldez fullname: Giráldez, Fernando – sequence: 7 givenname: Laura surname: Carramolino fullname: Carramolino, Laura – sequence: 8 givenname: Giovanna surname: Giovinazzo fullname: Giovinazzo, Giovanna – sequence: 9 givenname: Enrique surname: Vázquez fullname: Vázquez, Enrique – sequence: 10 givenname: Miguel surname: Torres fullname: Torres, Miguel – sequence: 11 givenname: Thomas surname: Schimmang fullname: Schimmang, Thomas |
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| Copyright | Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang. Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang. 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang |
| Copyright_xml | – notice: Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang. – notice: Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang. 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang |
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genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of... Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of... |
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| SubjectTerms | Cell and Developmental Biology cochlea inner ear Meis mouse organ of corti |
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| Title | Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea |
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