Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity

• Published in: Cardiovascular toxicology Vol. 21; no. 3; pp. 224 - 235
• Main Authors: do Vale, Gabriel T., da Silva, Carla B. P., Sousa, Arthur H., Gonzaga, Natália A., Parente, Juliana M., Araújo, Katiúscia M., Castro, Michele M., Tirapelli, Carlos R.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2021; Springer; Springer Nature B.V
• Subjects: Acetaldehyde; Alcohol; Alcohol, Denatured; Animals; Biomedical and Life Sciences; Biomedicine; Cardiology; Cardiomyopathy, Alcoholic - enzymology; Cardiomyopathy, Alcoholic - etiology; Cardiomyopathy, Alcoholic - pathology; Cardiomyopathy, Alcoholic - prevention & control; Catalase; Catalase - metabolism; CYBB protein; Disease Models, Animal; Ethanol; Gelatinase A; Gelatinase B; Glutathione; Heart; Heart Ventricles - drug effects; Heart Ventricles - enzymology; Heart Ventricles - pathology; Lipid Peroxidation - drug effects; Male; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - enzymology; Myocytes, Cardiac - pathology; NAD(P)H oxidase; NADPH Oxidase 2 - metabolism; Nebivolol; Nebivolol - pharmacology; Nitric Oxide Synthase Type III - metabolism; NOX4 protein; Oxidases; Pharmacology/Toxicology; Rac1 protein; Rats; Rats, Wistar; Redox properties; Superoxide; Superoxide dismutase; Superoxides - metabolism; Thiobarbituric acid; Tissue inhibitor of metalloproteinase 2; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Toxicity; Up-Regulation; Ventricle; Nebivolol; Reactive oxygen species; Matrix metalloproteinase; Ethanol; Left ventricle

Changes in redox state are described in the early stages of ethanol-induced cardiac toxicity. Here, we evaluated whether nebivolol would abrogate ethanol-induced redox imbalance in the heart. Male Wistar rats were treated with a solution of ethanol (20% v/v) for 3 weeks. Treatment with nebivolol (10...