Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum

• Published in: Nature communications Vol. 5; no. 1; p. 4446
• Main Authors: Clark, Martha A., Goheen, Morgan M., Fulford, Anthony, Prentice, Andrew M., Elnagheeb, Marwa A., Patel, Jaymin, Fisher, Nancy, Taylor, Steve M., Kasthuri, Raj S., Cerami, Carla
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.07.2014; Nature Publishing Group
• Subjects: 13; 13/106; 13/31; 14/19; 692/699/1541/13; 692/699/255/1629; Adult; Anemia; Anemia, Iron-Deficiency - drug therapy; Anemia, Iron-Deficiency - parasitology; Blood; Dietary Supplements; Disease Susceptibility; Erythrocytes - parasitology; Hemoglobin; Humanities and Social Sciences; Humans; Infections; Iron; Iron - blood; Iron - pharmacology; Malaria; Malaria, Falciparum - prevention & control; Medical research; Middle Aged; multidisciplinary; Parasites; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Plasmodium falciparum - pathogenicity; Science; Science (multidisciplinary); Young Adult; North Carolina; United States > US

Iron deficiency and malaria have similar global distributions, and frequently co-exist in pregnant women and young children. Where both conditions are prevalent, iron supplementation is complicated by observations that iron deficiency anaemia protects against falciparum malaria, and that iron supple...