New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum

Five linear fatty acid amides ( 1–5 ) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2′,3′-dihydroxy-α-sanshool and 2′,3′-dihydroxy-β-sanshool, res...

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Published in	Archives of pharmacal research Vol. 31; no. 5; pp. 569 - 572
Main Authors	Jang, Kyoung Hwa, Chang, Yong Ha, Kim, Dae-Duk, Oh, Ki-Bong, Oh, Uhtaek, Shin, Jongheon
Format	Journal Article
Language	English
Published	Heidelberg Pharmaceutical Society of Korea 01.05.2008 대한약학회
Subjects	Amides - chemistry Amides - isolation & purification Amides - pharmacology Cell Line, Tumor Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - pharmacology Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology Humans Medicine Pharmacology/Toxicology Pharmacy Zanthoxylum - chemistry 약학 Dihydroxy-α-sanshool Cytotoxicity Fatty acid amides Dihydroxy-β-sanshool Sanshools
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ISSN	0253-6269 1976-3786
DOI	10.1007/s12272-001-1194-5

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Summary:	Five linear fatty acid amides ( 1–5 ) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2′,3′-dihydroxy-α-sanshool and 2′,3′-dihydroxy-β-sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 G704-000010.2008.31.5.020
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-001-1194-5